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Volume 7, Pages 888-902
Review Article

Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

1Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
2Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Italy
3Department of Chemistry and Biochemistry, Université du Québec à Montréal, Montreal (Quebec), Canada
4Department of Biology, University of Rome, Italy
5Department of Biochemical Sciences “A. Rossi Fanelli”, Rome University “La Sapienza”, Rome, Italy

Received 8 November 2006; Revised 3 May 2007; Accepted 14 May 2007

Academic Editor: Salvatorre Cuzzocrea

Copyright © 2007 Emanuela Masini et al.


Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC1.4.3.6) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.