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Volume 7, Pages 224-232
Review Article


Department of Immunology, Berlex Biosciences, Richmond, CA, USA

Received 5 June 2006; Revised 28 July 2006; Accepted 9 November 2006

Academic Editor: Charles N. Serhan

Copyright © 2007 Richard Horuk.


Chemokines are a family of polypeptides that direct the migration of leukocytestoward a site of infection. They play a major role in autoimmune disease and chemokine receptors have recently been found to mediate HIV-1 fusion. In this short review we examine the role of chemokines in host defence and in the pathophysiology of autoimmune diseases. We conclude by discussing various therapeutic approaches that target chemokine receptors and that could be beneficial in disease.