The Scientific World Journal

The Scientific World Journal / 2008 / Article
Special Issue

Cardiac Development

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Review Article | Open Access

Volume 8 |Article ID 160851 | 31 pages | https://doi.org/10.1100/tsw.2008.40

Development of the Cardiac Conduction System and the Possible Relation to Predilection Sites of Arrhythmogenesis

Academic Editor: Robert E. Poelmann
Received23 Jul 2007
Revised10 Dec 2007
Accepted29 Jul 2008

Abstract

The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different properties than the surrounding working myocardium, which can be observed on a histological level, as well as by the expression patterns of several immunohistological and molecular markers. In recent years, many markers have been studied that have helped to elucidate the processes involved in CCS development. It has become clear that multiple genes, cells and their interactions are involved in this complex process. In this article, an overview of the current knowledge of CCS development is supplied. Furthermore, several controversies regarding conduction system development are discussed, as well as the possible significance of embryologic development of the CCS for the development of arrhythmias later in life.

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