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TheScientificWorldJOURNAL
Volume 9, Pages 1438-1448
http://dx.doi.org/10.1100/tsw.2009.166
Review Article

Trastuzumab Resistance: Role for Notch Signaling

1Molecular Biology Program, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA
2Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Maywood, IL, USA
3Molecular and Cellular Biochemistry Program, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL, USA

Received 3 June 2009; Revised 8 December 2009; Accepted 9 December 2009

Academic Editor: John D. Scott

Copyright © 2009 Kinnari Mehta and Clodia Osipo.

Citations to this Article [13 citations]

The following is the list of published articles that have cited the current article.

  • Xin Xu, Yu Zhao, Maozhong Xu, Qiuxin Dai, Wenjun Meng, Jiangang Yang, and Rujuan Qin, “Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia,” Medical Oncology, vol. 28, no. S1, pp. 483–489, 2010. View at Publisher · View at Google Scholar
  • Zhiwei Wang, Yiwei Li, Aamir Ahmad, Asfar S. Azmi, Dejuan Kong, Sanjeev Banerjee, and Fazlul H. Sarkar, “Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance,” Drug Resistance Updates, vol. 13, no. 4-5, pp. 109–118, 2010. View at Publisher · View at Google Scholar
  • Zhiwei Wang, Yiwei Li, Aamir Ahmad, Asfar S. Azmi, Sanjeev Banerjee, Dejuan Kong, and Fazlul H. Sarkar, “Targeting Notch signaling pathway to overcome drug resistance for cancer therapy,” Biochimica Et Biophysica Acta-Reviews On Cancer, vol. 1806, no. 2, pp. 258–267, 2010. View at Publisher · View at Google Scholar
  • Kazuya Nagano, “Search for breast cancer-related biomarker proteins for drug discovery,” Yakugaku Zasshi, vol. 130, no. 12, pp. 1701–1706, 2010. View at Publisher · View at Google Scholar
  • Christina Battke, Romana Ruiss, Ulrich Welsch, Pauline Wimberger, Stephan Lang, Simon Jochum, and Reinhard Zeidler, “Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC,” Cancer Immunology Immunotherapy, vol. 60, no. 5, pp. 639–648, 2011. View at Publisher · View at Google Scholar
  • H. Li, L. Hui, and W. Xu, “miR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2,” Acta Biochimica et Biophysica Sinica, vol. 44, no. 3, pp. 269–277, 2012. View at Publisher · View at Google Scholar
  • Roma Olsauskas-Kuprys, Andrei Zlobin, and Clodia Osipo, “Gamma secretase inhibitors of Notch signaling,” OncoTargets and Therapy, vol. 6, pp. 943–955, 2013. View at Publisher · View at Google Scholar
  • Morteza Aghmesheh, Akshat Saxena, and Farshid Niknam, “ BRCA 1 mutation site may be linked with nuclear DNA ploidy in BRCA 1 -mutated ovarian carcinomas ,” Asia-Pacific Journal of Clinical Oncology, 2014. View at Publisher · View at Google Scholar
  • Kinnari Pandya, and Clodia Osipo, “Gene amplification of ErbB-2: From gene to therapy,” Medical Radiology, vol. 63, pp. 7–13, 2014. View at Publisher · View at Google Scholar
  • Begoña Martin-Castillo, Eugeni Lopez-Bonet, Elisabet Cuyàs, Gemma Viñas, Sonia Pernas, Joan Dorca, and Javier A. Menendez, “Cancer stem cell-driven efficacy of trastuzumab (Herceptin): Towards a reclassification of clinically HER2-positive breast carcinomas,” Oncotarget, vol. 6, no. 32, pp. 32317–32338, 2015. View at Publisher · View at Google Scholar
  • Deep Shah, and Clodia Osipo, “Cancer stem cells and HER2 positive breast cancer: The story so far,” Genes & Diseases, 2016. View at Publisher · View at Google Scholar
  • Kinnari Pandya, Ian O. Ellis, Aleksandra Filipovic, Jason Sagert, Ajay Rana, Kathy S. Albain, Lucio Miele, Mitchell F. Denning, Clodia Osipo, Debra Wyatt, Brian Gallagher, Deep Shah, Andrew Baker, Jeffrey Bloodworth, Andrei Zlobin, Antonio Pannuti, and Andrew Green, “PKCα attenuates jagged-1-mediated notch signaling in ErbB-2-positive breast cancer to reverse trastuzumab resistance,” Clinical Cancer Research, vol. 22, no. 1, pp. 175–186, 2016. View at Publisher · View at Google Scholar
  • Xinmei Kang, Hui Wang, Qingyuan Zhang, Ximing Guo, Weiwei An, Xingjian Niu, Suhan Li, Yue Yang, Na Wang, Qicheng Jiang, Caichuan Yan, and Zhaoliang Liu, “Photothermal therapeutic application of gold nanorods-porphyrin-trastuzumab complexes in HER2-positive breast cancer,” Scientific Reports, vol. 7, 2017. View at Publisher · View at Google Scholar