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TheScientificWorldJOURNAL
Volume 9, Pages 1449-1462
http://dx.doi.org/10.1100/tsw.2009.159
Mini-Review Article

Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research

1Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA
2Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA

Received 5 August 2009; Revised 23 November 2009; Accepted 24 November 2009

Academic Editor: Rudy Tanzi

Copyright © 2009 Baomin Li et al.

Abstract

Syndromes of accelerated aging could provide an entry point for identifying and dissecting the cellular pathways that are involved in the development of age-related pathologies in the general population. However, their usefulness for aging research has been controversial, as it has been argued that these diseases do not faithfully reflect the process of natural aging. Here we review recent findings on the molecular basis of two progeroid diseases, Werner syndrome (WS) and Hutchinson-Gilford progeria syndrome (HGPS), and highlight functional connections to cellular processes that may contribute to normal aging.