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TheScientificWorldJOURNAL
Volume 9 (2009), Pages 1107-1118
http://dx.doi.org/10.1100/tsw.2009.128
Review Article

Urinary Exosomes

Institute of Immunology, Institute of Pathology, and Institute of Nephrology, Faculty of Medicine, University of Nis, Serbia

Received 25 May 2009; Revised 25 September 2009; Accepted 28 September 2009

Academic Editor: Ren-Wang Peng

Copyright © 2009 Irena Dimov et al.

Citations to this Article [36 citations]

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  • Bence Gyoergy, Tamas G. Szabo, Maria Pasztoi, Zsuzsanna Pal, Petra Misjak, Borbala Aradi, Valeria Laszlo, Eva Pallinger, Erna Pap, Agnes Kittel, Gyoergy Nagy, Andras Falus, and Edit I. Buzas, “Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles,” Cellular And Molecular Life Sciences, vol. 68, no. 16, pp. 2667–2688, 2011. View at Publisher · View at Google Scholar
  • Alton Etheridge, Inyoul Lee, Leroy Hood, David Galas, and Kai Wang, “Extracellular microRNA: A new source of biomarkers,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 717, no. 1-2, pp. 85–90, 2011. View at Publisher · View at Google Scholar
  • María-Paz Marzolo, and Pamela Farfán, “New insights into the roles of megalin/LRP2 and the regulation of its functional expression,” Biological Research, vol. 44, no. 1, pp. 89–105, 2011. View at Publisher · View at Google Scholar
  • Nils van der Lubbe, Pieter M. Jansen, Mahdi Salih, Robert A. Fenton, Anton H. van den Meiracker, A. H. Jan Danser, Robert Zietse, and Ewout J. Hoorn, “The Phosphorylated Sodium Chloride Cotransporter in Urinary Exosomes Is Superior to Prostasin as a Marker for Aldosteronism,” Hypertension, vol. 60, no. 3, pp. 741–+, 2012. View at Publisher · View at Google Scholar
  • M Lucrecia Alvarez, Mahdieh Khosroheidari, Rupesh Kanchi Ravi, and Johanna K DiStefano, “Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers,” Kidney International, vol. 82, no. 9, pp. 1024–1032, 2012. View at Publisher · View at Google Scholar
  • Doreen YP Fang, Hamish W King, Jordan YZ Li, and Jonathan M Gleadle, “Exosomes and the kidney: Blaming the messenger,” Nephrology, vol. 18, no. 1, pp. 1–10, 2012. View at Publisher · View at Google Scholar
  • Alessandro Allegra, Andrea Alonci, Salvatore Campo, Giuseppa Penna, Annamaria Petrungaro, Demetrio Gerace, and Caterina Musolino, “Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review),” International Journal Of Oncology, vol. 41, no. 6, pp. 1897–1912, 2012. View at Publisher · View at Google Scholar
  • Elham Hosseini-Beheshti, Steven Pham, Hans Adomat, Na Li, and Emma S. Tomlinson Guns, “Exosomes as biomarker enriched microvesicles: Characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes,” Molecular and Cellular Proteomics, vol. 11, no. 10, pp. 863–885, 2012. View at Publisher · View at Google Scholar
  • Aarthi Narayanan, Maria Iglesias-Ussel, Anastas Popratiloff, Ramin Hakami, Kylene Kehn-Hall, Mary Young, Caroline Subra, Caroline Gilbert, Charles Bailey, Fabio Romerio, Fatah Kashanchi, Sergey Iordanskiy, Ravi Das, Rachel Van Duyne, Steven Santos, Elizabeth Jaworski, Irene Guendel, Gavin Sampey, and Elizabeth Dalby, “Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA,” Journal of Biological Chemistry, vol. 288, no. 27, pp. 20014–20033, 2013. View at Publisher · View at Google Scholar
  • Hardip Sandhu, and Helen Maddock, “Molecular basis of cancer-therapy-induced cardiotoxicity: introducing microRNA biomarkers for early assessment of subclinical myocardial injury,” Clinical Science, vol. 126, no. 6, pp. 377–400, 2013. View at Publisher · View at Google Scholar
  • Kiyoshi Isobe, Takayasu Mori, Takako Asano, Hiroyuki Kawaguchi, Shigeaki Nonoyama, Naonori Kumagai, Fumiaki Kamada, Tetsuji Morimoto, Matsuhiko Hayashi, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, and Shinichi Uchida, “Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement,” American Journal of Physiology-Renal Physiology, vol. 305, no. 9, pp. F1374–F1381, 2013. View at Publisher · View at Google Scholar
  • M. Lucrecia Alvarez, and Johanna K. DiStefano, “The role of non-coding RNAs in diabetic nephropathy: Potential applications as biomarkers for disease development and progression,” Diabetes Research and Clinical Practice, vol. 99, no. 1, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Lin-Li Lv, Yuhan Cao, Dan Liu, Min Xu, Hong Liu, Ri-Ning Tang, Kun-Ling Ma, and Bi-Cheng Liu, “Isolation and Quantification of MicroRNAs from Urinary Exosomes/Microvesicles for Biomarker Discovery,” International Journal of Biological Sciences, vol. 9, no. 10, pp. 1021–1031, 2013. View at Publisher · View at Google Scholar
  • Abdelnaby Khalyfa, and David Gozal, “Exosomal miRNAs as potential biomarkers of cardiovascular risk in children,” Journal of Translational Medicine, vol. 12, 2014. View at Publisher · View at Google Scholar
  • Sujoy Dutta, Case Warshall, Chirosree Bandyopadhyay, Dipanjan Dutta, and Bala Chandran, “Interactions between Exosomes from Breast Cancer Cells and Primary Mammary Epithelial Cells Leads to Generation of Reactive Oxygen Species Which Induce DNA Damage Response, Stabilization of p53 and Autophagy in Epithelial Cells,” Plos One, vol. 9, no. 5, 2014. View at Publisher · View at Google Scholar
  • Jieping Yang, Fang Wei, Christopher Schafer, and David T. W. Wong, “Detection of Tumor Cell-Specific mRNA and Protein in Exosome-Like Microvesicles from Blood and Saliva,” Plos One, vol. 9, no. 11, 2014. View at Publisher · View at Google Scholar
  • Cristina Esteva-Font, Elena Guillen-Gomez, Joan Manuel Diaz, Luis Guirado, Carmen Facundo, Elisabet Ars, Jose A. Ballarin, and Patricia Fernandez-Llama, “Renal Sodium Transporters Are Increased in Urinary Exosomes of Cyclosporine-Treated Kidney Transplant Patients,” American Journal of Nephrology, vol. 39, no. 6, pp. 528–535, 2014. View at Publisher · View at Google Scholar
  • Nitu Kumari, Sunita Saxena, and Usha Agrawal, “Exosomal protein interactors as emerging therapeutic targets in urothelial bladder cancer,” Journal of the Egyptian National Cancer Institute, 2015. View at Publisher · View at Google Scholar
  • Gabriella Pocsfalvi, Christopher Stanly, Annalisa Vilasi, Immacolata Fiume, Giovambattista Capasso, Lilla Turiák, Edit I Buzas, and Károly Vékey, “Mass spectrometry of extracellular vesicles,” Mass Spectrometry Reviews, 2015. View at Publisher · View at Google Scholar
  • Stéphanie F. Glineur, Pierrette De Ron, Etienne Hanon, Jean-Pierre Valentin, Sarah Dremier, and André Nogueira da Costa, “Paving the Route to Plasma miR-208a-3p as an Acute Cardiac Injury Biomarker : Preclinical Rat Data Supports Its Use in Drug Safety Assessment,” Toxicological Sciences, pp. kfv222, 2015. View at Publisher · View at Google Scholar
  • Pietro Ivo D'Urso, Oscar Fernando D'Urso, Cosimo Damiano Gianfreda, Valeria Mezzolla, Carlo Storelli, and Santo Marsigliante, “miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma.,” Current genomics, vol. 16, no. 5, pp. 304–11, 2015. View at Publisher · View at Google Scholar
  • Mirja Krause, Anatoliy Samoylenko, and Seppo J. Vainio, “Exosomes as renal inductive signals in health and disease, and their application as diagnostic markers and therapeutic agents,” Frontiers in Cell and Developmental Biology, vol. 3, 2015. View at Publisher · View at Google Scholar
  • Joana Carvalho, Ihsan Gursel, Mayda Gursel, Niels H. H. Heegaard, An Hendrix, Peter Kierulf, Katsutoshi Kokubun, Maja Kosanovic, Veronika Kralj-Iglic, Eva-Maria Krämer-Albers, Cecilia Lässer, Thomas Lener, Aija Line, Alicia Llorente, Jan Lötvall, Mateja Manček-Keber, Irina Nazarenko, Esther N.M. Nolte-'t Hoen, Tuula A. Nyman, Lorraine O'Driscoll, Carla Oliveira, Jaume Reventós, Marina Rigau, Eva Rohde, Francesc E. Borràs, Marei Sammar, Katharina Schallmoser, Marie Stampe Ostenfeld, Willem Stoorvogel, Roman Stukelj, Helena Vasconcelos, Olivier De Wever, Krisztina Buzas, Enriqueta Casal, Francesco Cappello, María Yáñez-Mó, Eva Colás, Anabela Cordeiro-Da Silva, Stefano Fais, Juan M. Falcon-Perez, Irene M. Ghobrial, Bernd Giebel, Mario Gimona, Michael Graner, Pia R.-M. Siljander, Saara Laitinen, Zoraida Andreu, Erzsébet Ligeti, Georg Lipps, Antonio Marcilla, Maria Mittelbrunn, Apolonija Bedina Zavec, Mireia Olivan, Éva Pállinger, Hernando A. Del Portillo, Francisco Sánchez-Madrid, Santarém, Susanne G. Van Der Grein, Marca H. M. Wauben, and Edit I. Buzas, “Biological properties of extracellular vesicles and their physiological functions,” Journal of Extracellular Vesicles, vol. 4, no. 2015, pp. 1–60, 2015. View at Publisher · View at Google Scholar
  • Olga E. Bryzgunova, Vladimir E. Voitsitskiy, Evgeny A. Lekchnov, Alina E. Grigor'eva, Ivan A. Zaporozhchenko, Evgeny S. Morozkin, Elena I. Ryabchikova, Pavel P. Laktionov, Marat M. Zaripov, Tatyana E. Skvortsova, and Yuri B. Yurchenko, “Comparative study of extracellular vesicles from the urine of healthy individuals and prostate cancer patients,” PLoS ONE, vol. 11, no. 6, 2016. View at Publisher · View at Google Scholar
  • Yao Tong, Ya-Li Zhou, Yi-Xiao Wang, Pei-Quan Zhao, and Zhao-Yang Wang, “Retinal pigment epithelium cell-derived exosomes: Possible relevance to CNV in wet-age related macular degeneration,” Medical Hypotheses, vol. 97, pp. 98–101, 2016. View at Publisher · View at Google Scholar
  • Dear, Morrison, and Bailey, “Renal extracellular vesicles: from physiology to clinical application,” Journal of Physiology, vol. 594, no. 20, pp. 5735–5748, 2016. View at Publisher · View at Google Scholar
  • Gabriella Pocsfalvi, Christopher Stanly, Immacolata Fiume, and Károly Vékey, “Chromatography and its hyphenation to mass spectrometry for extracellular vesicle analysis,” Journal of Chromatography A, 2016. View at Publisher · View at Google Scholar
  • Clarissa Ruggeri, Sonia Gioffré, Felice Achilli, Gualtiero I. Colombo, and Yuri D’Alessandra, “Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients,” Heart Failure Reviews, 2017. View at Publisher · View at Google Scholar
  • Leila Kheirandish-Gozal, Abdelnaby Khalyfa, and David Gozal, “Exosomes, blood?brain barrier, and cognitive dysfunction in pediatric sleep apnea,” Sleep and Biological Rhythms, 2017. View at Publisher · View at Google Scholar
  • Margherita A. C. Pomatto, Chiara Gai, Benedetta Bussolati, and Giovanni Camussi, “Extracellular Vesicles in Renal Pathophysiology,” Frontiers in Molecular Biosciences, vol. 4, 2017. View at Publisher · View at Google Scholar
  • Joel Henrique Ellwanger, Tiago Degani Veit, and José Artur Bogo Chies, “Exosomes in HIV infection: A review and critical look,” Infection, Genetics and Evolution, 2017. View at Publisher · View at Google Scholar
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  • Isabella Panfoli, “Cancer exosomes in urine: A promising biomarker source,” Translational Cancer Research, vol. 6, pp. S1389–S1393, 2017. View at Publisher · View at Google Scholar
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  • Brighton E Maburutse, Mi-Ri Park, Sangnam Oh, and Younghoon Kim, “Evaluation and Characterization of Milk-derived Microvescicle Isolated from Bovine Colostrum.,” Korean journal for food science of animal resources, vol. 37, no. 5, pp. 654–662, 2017. View at Publisher · View at Google Scholar
  • Marianna Gyurászová, Alexandra Kovalčíková, Janka Bábíčková, Július Hodosy, and Ľubomíra Tóthová, “Cell-free nucleic acids in urine as potential biomarkers of kidney disease,” Journal of Applied Biomedicine, 2018. View at Publisher · View at Google Scholar