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TheScientificWorldJOURNAL
Volume 10, Pages 1667-1678
http://dx.doi.org/10.1100/tsw.2010.154
Mini-Review Article

Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer’'s Disease

1Laboratory for Alzheimer's Disease and Aging Research, VA Medical Center, Kansas City, MO, USA
2Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA
3Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA

Received 21 January 2010; Revised 29 June 2010; Accepted 6 July 2010

Academic Editor: Rudy Tanzi

Copyright © 2010 William Z. Suo and Longxuan Li.

Citations to this Article [21 citations]

The following is the list of published articles that have cited the current article.

  • Shaowu Cheng, Longxuan Li, Shuangteng He, Jun Liu, Yuning Sun, Minchao He, Kenneth Grasing, Richard T. Premont, and William Z. Suo, “GRK5 deficiency accelerates β-amyloid accumulation in Tg2576 mice via impaired cholinergic activity,” Journal of Biological Chemistry, vol. 285, no. 53, pp. 41541–41548, 2010. View at Publisher · View at Google Scholar
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  • Yun Zhang, Guang-li Shen, Li-juan Shangguan, Yang Yu, and Mao-lin He, “Involvement of NFκB signaling in mediating the effects of GRK5 on neural stem cells,” Brain Research, 2015. View at Publisher · View at Google Scholar
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  • Tsevelmaa Nanjidsuren, Chae-Won Park, Bo-Woong Sim, Sun-Uk Kim, Kyu-Tae Chang, Myung-Hwa Kang, and Kwan-Sik Min, “GRK5-Knockout Mice Generated by TALEN-Mediated Gene Targeting,” Animal Biotechnology, vol. 27, no. 4, pp. 223–230, 2016. View at Publisher · View at Google Scholar
  • William Z. Suo, “Roles of GRK Dysfunction in Alzheimer’s Pathogenesis,” G Protein-Coupled Receptor Kinases, pp. 215–236, 2016. View at Publisher · View at Google Scholar
  • Minchao He, Prabhakar Singh, Shaowu Cheng, Qiang Zhang, Wei Peng, XueFeng Ding, Longxuan Li, Jun Liu, Richard T. Premont, Dave Morgan, Jeffery M. Burns, Russell H. Swerdlow, and William Z. Suo, “GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability,” Scientific Reports, vol. 6, pp. 26116, 2016. View at Publisher · View at Google Scholar
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  • Prabhakar Singh, Wei Peng, Qiang Zhang, XueFeng Ding, and William Z. Suo, “GRK5 deficiency leads to susceptibility to intermittent hypoxia-induced cognitive impairment,” Behavioural Brain Research, 2016. View at Publisher · View at Google Scholar
  • Yuan Zhang, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cui, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, and Ting Chen, “The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk.,” Oncotarget, vol. 8, no. 42, pp. 72714–72726, 2017. View at Publisher · View at Google Scholar
  • Maradumane L. Mohan, Neelakantan T. Vasudevan, and Sathyamangla V. Naga Prasad, “Proinflammatory Cytokines Mediate GPCR Dysfunction,” Journal of Cardiovascular Pharmacology, vol. 70, no. 2, pp. 61–73, 2017. View at Publisher · View at Google Scholar
  • Xiangchang Zeng, Siyu Chen, Qing Gao, Wenjing Zong, Dejian Jiang, Guirong Zeng, Luping Zhou, Lulu Chen, Wei Luo, Jian Xiao, Bo Xiao, Dongsheng Ouyang, and Kai Hu, “The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus,” Epilepsy Research, vol. 138, pp. 62–70, 2017. View at Publisher · View at Google Scholar
  • Michael D. Steury, Laura R. McCabe, and Narayanan Parameswaran, “G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling,” 2017. View at Publisher · View at Google Scholar
  • Helen V. Waldschmidt, Renee Bouley, Paul D. Kirchhoff, Pil Lee, John J.G. Tesmer, and Scott D. Larsen, “Utilizing a Structure-Based Docking Approach to Develop Potent G Protein-Coupled Receptor Kinase (GRK) 2 and 5 Inhibitors,” Bioorganic & Medicinal Chemistry Letters, 2018. View at Publisher · View at Google Scholar
  • Mary Gannon, and Qin Wang, “Complex Noradrenergic Dysfunction in Alzheimer’s Disease: Low Norepinephrine Input is Not Always to Blame,” Brain Research, 2018. View at Publisher · View at Google Scholar