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TheScientificWorldJOURNAL
Volume 10, Pages 1067-1072
http://dx.doi.org/10.1100/tsw.2010.106
Review Article

Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols

1Departamento de Química, Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, Brazil
2Departamento de Parasitologia, Microbiologia e Imunologia Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, Brazil

Received 4 February 2010; Revised 26 April 2010; Accepted 9 May 2010

Academic Editor: Paul Cos

Copyright © 2010 Roberta Novaes Reis Corrales et al.

Abstract

In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an aliphatic moiety with eight to 12 carbon atoms displayed a good activity against L. amazonensis and L. major, and two of them also showed antiproliferative activity against L. chagasi. The best results were obtained for the N-dodecanoyl ethylenediamine derivative and for N-decyl aminoalcohol (IC50 = 5.2 and 0.7 μM, respectively).