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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 1169-1173
http://dx.doi.org/10.1100/tsw.2010.139
Case Study

Xanthogranulomatous Cystitis: A Challenging Imitator of Bladder Cancer

1Department of Urology, School of Medicine, Maltepe University, Istanbul, Turkey
2Department of Urology, School of Medicine, Yeditepe University, Istanbul, Turkey
3Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkey
4Department of Pathology, School of Medicine, Maltepe University, Istanbul, Turkey

Received 28 January 2010; Revised 6 June 2010; Accepted 15 June 2010

Academic Editor: Anthony Atala

Copyright © 2010 Sinan Ekici et al.

Abstract

Xanthogranulomatous cystitis is a rare, benign, chronic inflammatory disease of the bladder, mimicking malignancy with unknown etiology. Herein, we report a 57-year-old man who presented with pollakiuria, nocturia, dysuria, left flank pain, and a palpable mass on the right lower abdomen. Computerized tomography demonstrated an obstructing 10-mm stone in the lower third of the left ureter and a 6-cm solid mass on the right at the anterolateral wall of the bladder. The mass presented local perivesical invasion at the anterolateral side. Cystouretroscopy revealed a mass protruding into the bladder cavity with edematous smooth surface. Frozen section analysis of the partial cystectomy specimen could not rule out malignancy. Therefore, radical cystoprostatectomy and ureterolithotomy were performed. Histologically, fibrosis, numerous plasma cells, eosinophils, and, immunohistochemically, CD68-positive epithelioid and foamy macrophages were detected. Localized prostatic adenocarcinoma was also found. The present case of xanthogranulomatous cystitis is the 23rd to be reported in the world literature.