The Scientific World Journal

The Scientific World Journal / 2010 / Article

Review Article | Open Access

Volume 10 |Article ID 640781 |

Andrés D. Maturana, Toshitsugu Fujita, Shun'ichi Kuroda, "Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain", The Scientific World Journal, vol. 10, Article ID 640781, 9 pages, 2010.

Functions of Fasciculation and Elongation Protein Zeta-1 (FEZ1) in the Brain

Academic Editor: Paul H. Patterson
Received16 Mar 2010
Revised09 Jun 2010
Accepted30 Jun 2010


Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. Recently, proteomic techniques revealed that FEZ1 interacts with various intracellular partners, such as signaling, motor, and structural proteins. FEZ1 was shown to act as an antiviral factor. The findings reported so far indicate that FEZ1 is associated with neuronal development, neuropathologies, and viral infection. Based on these accumulating evidences, we herein review the biological functions of FEZ1.

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