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TheScientificWorldJOURNAL
Volume 10 (2010), Pages 161-177
http://dx.doi.org/10.1100/tsw.2010.8
Review Article

Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain

Division of Neurogerontology, Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA

Received 11 December 2009; Accepted 17 December 2009

Academic Editor: Rudy Tanzi

Copyright © 2010 Edoardo Parrella and Valter D. Longo.

Citations to this Article [24 citations]

The following is the list of published articles that have cited the current article.

  • Alexios-Fotios A. Mentis, and Evangelia Kararizou, “Does ageing originate in utero?,” Biogerontology, vol. 11, no. 6, pp. 725–729, 2010. View at Publisher · View at Google Scholar
  • Claus Zabel, Huu Phuc Nguyen, Sascha C. Hin, Daniela Hartl, Lei Mao, and Joachim Klose, “Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders,” Journal of Proteomics, vol. 73, no. 11, pp. 2230–2238, 2010. View at Publisher · View at Google Scholar
  • Arnold De Loof, “Longevity and aging in insects: Is reproduction costly; cheap; beneficial or irrelevant? A critical evaluation of the "trade-off" concept,” Journal Of Insect Physiology, vol. 57, no. 1, pp. 1–11, 2011. View at Publisher · View at Google Scholar
  • Mark A. McCormick, Shih-yin Tsai, and Brian K. Kennedy, “TOR and ageing: a complex pathway for a complex process,” Philosophical Transactions Of The Royal Society B-Biological Sciences, vol. 366, no. 1561, pp. 17–27, 2011. View at Publisher · View at Google Scholar
  • Isaac Kremsky, Todd E. Morgan, Xiaogang Hou, Lei Li, and Caleb E. Finch, “Age-changes in gene expression in primary mixed glia cultures from young vs. old rat cerebral cortex are modified by interactions with neurons,” Brain, Behavior, and Immunity, vol. 26, no. 5, pp. 797–802, 2012. View at Publisher · View at Google Scholar
  • Emanuel Candeias, Ana I. Duarte, Cristina Carvalho, Sónia C. Correia, Susana Cardoso, Renato X. Santos, Ana I. Plácido, George Perry, and Paula I. Moreira, “The impairment of insulin signaling in Alzheimer's disease,” IUBMB Life, vol. 64, no. 12, pp. 951–957, 2012. View at Publisher · View at Google Scholar
  • Daniele Campa, Roberto Barale, Francesco de Rango, Maura Carrai, Paolina Crocco, Alberto Montesanto, Federico Canzian, Giuseppina Rose, Cosmeri Rizzato, and Giuseppe Passarino, “Bitter Taste Receptor Polymorphisms and Human Aging,” PLoS ONE, vol. 7, no. 11, 2012. View at Publisher · View at Google Scholar
  • Antonio Diez-Juan, and Jaime Font de Mora, “The decay of stem cell nourishment at the niche.,” Rejuvenation Research, pp. 130812153748008, 2013. View at Publisher · View at Google Scholar
  • Hui-Li Feng, Rui-Sheng Li, Hong Wang, Ying Ren, Hai-Yun Sun, Jin-Duo Yang, and Peng-Wen Wang, “Effect of curcumin on hippocampal IRS-1 and p-IRS-1 expressions in APP/PS1 double transgenic mice,” Zhongguo Zhongyao Zazhi, vol. 38, no. 9, pp. 1290–1294, 2013. View at Publisher · View at Google Scholar
  • Edoardo Parrella, Tom Maxim, Francesca Maialetti, Lu Zhang, Junxiang Wan, Min Wei, Pinchas Cohen, Luigi Fontana, and Valter D. Longo, “Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model,” Aging Cell, vol. 12, no. 2, pp. 257–268, 2013. View at Publisher · View at Google Scholar
  • Jung-Won Soh, Nicholas Marowsky, Thomas J. Nichols, Abid M. Rahman, Tayaba Miah, Paraminder Sarao, Rawia Khasawneh, Archana Unnikrishnan, Ahmad R. Heydari, Robert B. Silver, and Robert Arking, “Curcumin is an early-acting stage-specific inducer of extended functional longevity in Drosophila,” Experimental Gerontology, vol. 48, no. 2, pp. 229–239, 2013. View at Publisher · View at Google Scholar
  • Margaret B. Wierman, and Jeffrey S. Smith, “Yeast sirtuins and the regulation of aging,” FEMS Yeast Research, 2013. View at Publisher · View at Google Scholar
  • Arnold De Loof, Wouter De Haes, Bart Boerjan, and Liliane Schoofs, “The Fading Electricity Theory of Ageing: The missing biophysical principle?,” Ageing Research Reviews, vol. 12, no. 1, pp. 58–66, 2013. View at Publisher · View at Google Scholar
  • A. M. Vaiserman, A. K. Koliada, and O. G. Zabuga, “Effect of dietary restriction during development on the level of expression of longevity-associated genes in Drosophila melanogaster,” Advances in Gerontology, vol. 4, no. 3, pp. 193–196, 2014. View at Publisher · View at Google Scholar
  • Stephen T. Trumbo, and Claudia M. Rauter, “Juvenile hormone, metabolic rate, body mass and longevity costs in parenting burying beetles,” Animal Behaviour, vol. 92, pp. 203–211, 2014. View at Publisher · View at Google Scholar
  • Alexey A Moskalev, Alexander M Aliper, Zeljka Smit-McBride, Anton Buzdin, and Alex Zhavoronkov, “Genetics and epigenetics of aging and longevity,” Cell Cycle, vol. 13, no. 7, 2014. View at Publisher · View at Google Scholar
  • Jeroen P. Kooman, Peter Kotanko, Annemie M. W. J. Schols, Paul G. Shiels, and Peter Stenvinkel, “Chronic kidney disease and premature ageing,” Nature Reviews Nephrology, 2014. View at Publisher · View at Google Scholar
  • Krishnendu Mukherjee, Richard M. Twyman, and Andreas Vilcinskas, “Insects as models to study the epigenetic basis of disease,” Progress in Biophysics and Molecular Biology, 2015. View at Publisher · View at Google Scholar
  • John P. Aris, Laura K. Fishwick, Michelle L. Marraffini, Arnold Y. Seo, Christiaan Leeuwenburgh, and William A. Dunn, “Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae,” Sub-Cellular Biochemistry, vol. 57, pp. 161–186, 2015. View at Publisher · View at Google Scholar
  • Xiyan Li, and Michael P Snyder, “Yeast longevity promoted by reversing aging-associated decline in heavy isotope content,” npj Aging and Mechanisms of Disease, vol. 2, no. 1, 2016. View at Publisher · View at Google Scholar
  • Esmeralda Giovannetti, Katia Aquilano, and Daniele Lettieri-Barbato, “Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human,” Aging, vol. 8, no. 12, pp. 3341–3355, 2016. View at Publisher · View at Google Scholar
  • Gil B. Carvalho, Ilaria Drago, Sany Hoxha, Ryuichi Yamada, Olena Mahneva, Kimberley D. Bruce, Alina Soto Obando, Bruno Conti, and William W. Ja, “ The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan ,” Proceedings of the National Academy of Sciences, pp. 201618994, 2017. View at Publisher · View at Google Scholar
  • Roberta Buono, and Valter D. Longo, “Starvation, Stress Resistance, and Cancer,” Trends in Endocrinology & Metabolism, 2018. View at Publisher · View at Google Scholar
  • Michael Hook, Suheeta Roy, Evan G. Williams, Maroun Bou Sleiman, Khyobeni Mozhui, James F. Nelson, Lu Lu, Johan Auwerx, and Robert W. Williams, “Genetic cartography of longevity in humans and mice: Current landscape and horizons,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018. View at Publisher · View at Google Scholar