Macrophage Polarization in Health and Disease

Table 1

Subpopulations of macrophages in different pathologies.

Disease	Markers	References
Cancer
Invasive macrophages	WNT^+, EGF^+	[25–28]
Activated macrophages	IL-12^+, MHC II^HI, TNF-𝛼^+, CD80/86^+	[29, 30]
Immunosuppressive macrophages	Arginase^+, MARCO^+, IL-10^+, CCL-22^+	[31, 32]
Angiogenic macrophages	VEGFR1^+, VEGF^+, CXCR4^+, Tie2^+, EST2^+	[33–36]
Metastasis-associated macrophages	VEGFR1^+, CXCR4^-, CCR2^+, Tie2^-	[24, 37–39]
FoxP3^+ macrophages (regulatory macrophages)	PGE2, Arg-2, IL-1α, CXCL4, CCL7, CCL9, CXCL12, CXCL13, PDGF, and VEGF	[40]
HIV
HIV-transmitting macrophages	DC-SIGN^+, CD163, CD206, High Phagocytosis	(Cassol et al., submitted)
HIV-resistant macrophages	APOBEC3A^+, Low phagocytosis	(Cassetta et al., submitted)
Other
Perivascular macrophages	Phagocytosis	[41, 42]