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TheScientificWorldJOURNAL
Volume 11, Pages 2115-2123
http://dx.doi.org/10.1100/2011/263137
Case Report

Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin

1Servicio de Nefrología, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, Spain
2Servicio de Radiología, Hospital Universitario La Paz, 28046 Madrid, Spain
3Area de Tecnología de la Información, SESCAM, 45071 Toledo, Spain

Received 15 July 2011; Accepted 4 October 2011

Academic Editor: Daniel Batlle

Copyright © 2011 Ramón Peces et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid growth from renal AMLs and development of LAM may occur with successive pregnancies. It also stresses the potential for preservation of renal function despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs.