Review Article
[Retracted] A Showcase of Bench-to-Bedside Regenerative Medicine at the 2010 ASNTR
Table 2
Summary of Parkinson’s disease studies at the 2010 ASNTR meeting.
| | Disease pathology | Models | Neuroprotection | Transplant | Treatments |
| Morphological Etc | BBB impairment [5, 6] Rapid loss of striatal DA innervations [25] calcium [35] | Rotenone [3, 4] | Uncoupling proteins [13] | Cografts [33], tissue + calcium channel inhibitors [34], NPCs [36, 37], hMSCs [40] | DA receptor agonist [24], antidepressants [26], DBS [27–29] |
| Gene therapy | | | -Synuclein silencing [14], pleiotrophin [15] | GDNF + NPCs [38], GDNF + hUCB [39] | |
| Inflammation | Increased [8, 9, 11] DA toxicity [12] | | Reduced microglial activation [10] | | Allantoin [21] PPAR- [22] |
| Growth factors | Fetal-antigen 1 overexpression in striatum [16] GDNF and development [19] | | CDNF [20] | GDNF + tissue grafts [17, 18] | |
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