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Volume 11, Pages 1781-1787
Research Article

Pregnancy Rates with Recombinant versus Urinary Human Chorionic Gonadotropin in In Vitro Fertilization: An Observational Study

1Infertility Center of Buda, Szt János Hospital, H-1125 Budapest, Hungary
2Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, H-1083 Budapest, Hungary
3Department of Laboratory Medicine, Semmelweis University, H-1083 Budapest, Hungary
4Department of Obstetrics and Gynecology, Mór Kaposi University Teaching Hospital, H-7400 Kaposvár, Hungary

Received 14 September 2011; Accepted 12 October 2011

Academic Editor: Takeshige Otoi

Copyright © 2011 József Zeke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Randomized clinical trials (RCTs) demonstrated the equal efficacy of urinary human chorionic gonadotropin (uhCG) and recombinant hCG (rhCG) products in in vitro fertilisation (IVF). However, limitations inherent with RCTs necessitate the reinforcement of RCT results in real-life. We retrospectively analyzed pregnancies after treatment with rhCG and uhCG products ( 𝑛 = 3 9 1 , and 96, resp.). We found that laboratory-verified pregnancy occurred more frequently in rhCG patients than in those on uhCG (43% versus 30%, 𝑃 = 0 . 0 2 ). The association remains significant ( 𝑃 = 0 . 0 0 2 ) after its adjustment for clinical characteristics. The prevalence of laboratory-verified pregnancies was higher with GnRH agonist use ( 𝑃 = 0 . 0 1 2 ) and BMI under 30 kg/m2 ( 𝑃 = 0 . 0 5 3 ) while decreased the age ( 𝑃 = 0 . 0 1 4 ) and the number of previous failed attempts ( 𝑃 = 0 . 0 8 ). Similar (but not significant) trends were observed with rates of pregnancy filled the 24th week. These results reinforce RCTs supporting the notion that rhCG is more efficient as uhCG during IVF.