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TheScientificWorldJOURNAL
Volume 11, Pages 161-172
http://dx.doi.org/10.1100/tsw.2011.21
Mini-Review Article

Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia

1Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
2Department of Hematology, ICO-Hospital Duran i Reynals, Barcelona, Spain

Received 21 September 2010; Revised 3 December 2010; Accepted 17 December 2010

Academic Editor: Edward J. Benz

Copyright © 2011 Julio Delgado and Rafael F. Duarte.

Abstract

Allogeneic hematopoietic cell transplantation has become a viable option for younger patients with poor-risk chronic lymphocytic leukemia. The results obtained with either conventional or reduced-intensity conditioning regimens have been recently evaluated and compared with alternative nontransplant strategies. This manuscript deals with practical aspects of the procedure, including patient and donor selection, conditioning regimen, GVHD prophylaxis, disease monitoring, infectious and noninfectious complications, and timing of the procedure. Finally, we speculate on how we could improve the results obtained with the procedure and new advances currently in clinical trials.