Review Article

Midkine in Inflammation

Table 1

Overview of the role of MK in chronic inflammatory diseases.

OrganDiseaseModel/specimenPublication

KidneyDiabetic nephropathyStreptozotocin-induced diabetic nephropathyKosugi et al. 2006 [28], Kosugi et al. 2007 [10]
Tubulointerstitial injuryIschemia/reperfusionSato et al. 2001 [29],
Sato et al. 2005 [30]
Drug side effectsCisplatin-induced renal damageKawai et al. 2004 [31]

JointsRheumatoid arthritisHuman synovial fluid, human synovial tissueTakada et al. 1997 [32]
Antitype II collagen antibody-induced arthritisMaruyama et al. 2004 [11]

Vascular SystemAtherosclerosisIntimal hyperplasia in vein graftsBanno et al. 2006 [33]
In-stent restenosisNarita et al. 2008 [34]
Neointima formation in restenosisHoriba et al. 2000 [35]

ColonCrohn's diseaseHuman bloodKrzystek-Korpacka et al. 2010 [12]
Ulcerative colitisDextran-sulfate-sodium- (DSS-) induced colitisYuki et al. 2006 [36]

Central nervous systemMultiple sclerosisExperimental autoimmune encephalomyelitis (EAE)Liu et al. 1998 [37],
Wang et al. 2008 [13]