Table of Contents Author Guidelines Submit a Manuscript
TheScientificWorldJOURNAL
Volume 11, Pages 1886-1892
http://dx.doi.org/10.1100/2011/583603
Research Article

Comparative Effects of Triflusal, S-Adenosylmethionine, and Dextromethorphan over Intestinal Ischemia/Reperfusion Injury

1Departamento de Fisiología, Facultad de Medicina, UANL, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Col. Mitras Centro, 64460 Monterrey, NL, Mexico
2Departamento de Medicina Interna, Facultad de Medicina, Universidad Autónoma de Nuevo León, 64460 Monterrey, NL, Mexico
3Unidad de Hígado, Departamento de Medicina Interna, Facultad de Medicina, Universidad Autónoma de Nuevo León, 64460 Monterrey, NL, Mexico
4Servicio de Anatomía Patológica y Citopatología, Hospital Universitario “José Eleuterio González,” 64460 Monterrey, NL, Mexico

Received 27 August 2011; Accepted 12 October 2011

Academic Editor: Huaxin Sheng

Copyright © 2011 Carlos R. Cámara-Lemarroy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. H. Mallick, W. Yang, M. C. Winslet, and A. M. Seifalian, “Ischemia-reperfusion injury of the intestine and protective strategies against injury,” Digestive Diseases and Sciences, vol. 49, no. 9, pp. 1359–1377, 2004. View at Publisher · View at Google Scholar
  2. S. E. Kong, L. R. Blennerhassett, K. A. Heel, R. D. Mccauley, and J. C. Hall, “Ischaemia-reperfusion injury to the intestine,” Australian and New Zealand Journal of Surgery, vol. 68, no. 8, pp. 554–561, 1998. View at Google Scholar
  3. J. A. González-Correa and J. P. de la Cruz, “Triflusal: an antiplatelet drug with a neuroprotective effect?” Cardiovascular Drug Reviews, vol. 24, no. 1, pp. 11–24, 2006. View at Publisher · View at Google Scholar · View at PubMed
  4. S. N. Whitehead, N. A. Bayona, G. Cheng, G. V. Allen, V. C. Hachinski, and D. F. Cechetto, “Effects of triflusal and aspirin in a rat model of cerebral ischemia,” Stroke, vol. 38, no. 2, pp. 381–387, 2007. View at Publisher · View at Google Scholar · View at PubMed
  5. C. S. Lieber, “S-adenosyl-L-methionine: its role in the treatment of liver disorders,” American Journal of Clinical Nutrition, vol. 76, no. 5, pp. 1183S–1187S, 2002. View at Google Scholar
  6. M. A. Villalobos, J. P. de la Cruz, M. A. Cuerda, P. Ortiz, J. M. Smith-Agreda, and F. S. de la Cuesta, “Effect of S-adenosyl-L-methionine on rat brain oxidative stress damage in a combined model of permanent focal ischemia and global ischemia-reperfusion,” Brain Research, vol. 883, no. 1, pp. 31–40, 2000. View at Publisher · View at Google Scholar
  7. Y. B. Lee and S. M. Lee, “Effect of S-adenosylmethionine on hepatic injury from sequential cold and warm ischemia,” Archives of Pharmacal Research, vol. 23, no. 5, pp. 495–500, 2000. View at Google Scholar
  8. P. M. Bokesch, J. E. Marchand, C. S. Connelly, W. H. Wurm, and R. M. Kream, “Dextromethorphan inhibits ischemia-induced c-fos expression and delayed neuronal death in hippocampal neurons,” Anesthesiology, vol. 81, no. 2, pp. 470–477, 1994. View at Google Scholar
  9. R. Ben-Abraham, M. Guttman, R. Flaishon, N. Marouani, D. Niv, and A. A. Weinbroum, “Mesenteric artery clamping/unclamping-induced acute lung injury is attenuated by N-methyl-D-aspartate antagonist dextromethorphan,” Lung, vol. 184, no. 6, pp. 309–317, 2006. View at Publisher · View at Google Scholar · View at PubMed
  10. C. R. Cámara, F. J. Guzmán, E. A. Barrera et al., “Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats,” World Journal of Gastroenterology, vol. 14, no. 33, pp. 5192–5196, 2008. View at Publisher · View at Google Scholar
  11. T. V. Arumugam, N. Arnold, L. M. Proctor et al., “Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist,” British Journal of Pharmacology, vol. 140, no. 1, pp. 71–80, 2003. View at Publisher · View at Google Scholar · View at PubMed
  12. S. Massberg, G. Enders, R. Leiderer et al., “Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectin,” Blood, vol. 92, no. 2, pp. 507–515, 1998. View at Google Scholar
  13. Y. Bayón, A. Alonso, and M. S. Crespo, “4-Trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor κB activation,” British Journal of Pharmacology, vol. 126, no. 6, pp. 1359–1366, 1999. View at Google Scholar
  14. M. Aceves, A. Dueñas, C. Gómez, E. San Vicente, M. S. Crespo, and C. García-Rodríguez, “A new pharmacological effect of salicylates: inhibition of NFAT-dependent transcription,” Journal of Immunology, vol. 173, no. 9, pp. 5721–5729, 2004. View at Google Scholar
  15. A. Ma, S. Qi, and H. Chen, “Antioxidant therapy for prevention of inflammation, ischemic reperfusion injuries and allograft rejection,” Cardiovascular and Hematological Agents in Medicinal Chemistry, vol. 6, no. 1, pp. 20–43, 2008. View at Publisher · View at Google Scholar
  16. H. Jefferies, J. Bot, J. Coster, A. Khalil, J. C. Hall, and R. D. McCauley, “The role of glutathione in intestinal dysfunction,” Journal of Investigative Surgery, vol. 16, no. 6, pp. 315–323, 2003. View at Google Scholar
  17. H. S. Oz, T. S. Chen, C. J. McClain, and W. J. S. de Villiers, “Antioxidants as novel therapy in a murine model of colitis,” Journal of Nutritional Biochemistry, vol. 16, no. 5, pp. 297–304, 2005. View at Publisher · View at Google Scholar · View at PubMed
  18. J. Yu, S. Sauter, and A. Parlesak, “Suppression of TNF-α production by S-adenosylmethionine in human mononuclear leukocytes is not mediated by polyamines,” Biological Chemistry, vol. 387, no. 12, pp. 1619–1627, 2006. View at Publisher · View at Google Scholar · View at PubMed
  19. L. Llacuna, M. Marí, J. M. Lluis, C. García-Ruiz, J. C. Fernández-Checa, and A. Morales, “Reactive oxygen species mediate liver injury through parenchymal nuclear factor-κB inactivation in prolonged ischemia/reperfusion,” American Journal of Pathology, vol. 174, no. 5, pp. 1776–1785, 2009. View at Publisher · View at Google Scholar · View at PubMed
  20. C. R. Cámara-Lemarroy, F. J. Guzmán-de la Garza, G. Alarcón-Galván, P. Cordero-Pérez, and N. E. Fernández-Garza, “The effects of NMDA receptor antagonists over intestinal ischemia/reperfusion injury in rats,” European Journal of Pharmacology, vol. 621, no. 1–3, pp. 78–85, 2009. View at Publisher · View at Google Scholar · View at PubMed
  21. F. J. G. Garza, C. R. Cámara-Lemarroy, R. G. Ballesteros-Elizondo, G. Alarcón-Galván, P. Cordero-Pérez, and N. E. Fernández-Garza, “Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats,” Surgery Today, vol. 40, no. 11, pp. 1055–1062, 2010. View at Publisher · View at Google Scholar · View at PubMed
  22. G. Li, Y. Liu, N. S. Tzeng et al., “Protective effect of dextromethorphan against endotoxic shock in mice,” Biochemical Pharmacology, vol. 69, no. 2, pp. 233–240, 2005. View at Publisher · View at Google Scholar · View at PubMed
  23. S. L. Liu, Y. H. Li, G. Y. Shi et al., “Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice,” Cardiovascular Research, vol. 82, no. 1, pp. 161–169, 2009. View at Publisher · View at Google Scholar · View at PubMed