Overlapping, Additive and Counterregulatory Effects of Type II and I Interferons on Myeloid Dendritic Cell Functions

Table 1

Type II and I IFN overlapping effects on dendritic cells. The scheme depicted resumes the most important overlapping effects of type II and I IFNs on DCs. Numbers refer to references as reported in the References section.

IFN-γ	IFN-γ and IFN-α/β overlapping effects	IFN-α/β
[17, 26, 27]	Potentiate CD40L stimulation of DCs	[2, 28–32]
[17, 33]	Potentiate CD8 T-cell stimulation by DCs	[34]
[17, 21, 33]	Potentiate IFN-γ production, by cocultured T cells	[17, 21, 33]
[17, 26, 27, 32, 35]	Potentiate IL-12p70 and IL-6 production, by DCs	[17, 26, 27, 32, 35]
[17, 21]	Potentiate CCR7-driven migration of DCs (controversial)	[24, 25, 32, 36, 37]
[17, 38, 39]	Induce CD38 in DCs	[28, 40]
[26, 27, 35, 41, 42]	Stimulate production of CXCL9 and CXCL10 by DCs	[24, 25, 43]
[8, 44–48]	Can block APC capacity of DCs (via expression of B7-H1 and IDO by DCs)	[49]
[8, 50]	Potentiate IL-27 production by DCs, reduce OPN	[2, 28, 51–58]
[17, 26, 27]	Upregulate MHC class I (and II) molecules in DCs	[59, 60]
[61–64]	Increase IL-15 production and transpresentation by DCs	[61, 62, 65–70]
To be tested	Increase T and NK cells activation and maintenance	[60]
Frasca and Lande, unpublished	Induce CD70 upregulation on DCs	Frasca and Lande, unpublished [63, 71]