Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside

Figure 2

(A) After linking between TCR and MHC-peptide and after coreceptor CD4 engagement, LCK and Fyn kinases are activated. LCK and Fyn in turn phosphorylate TCR complex and c-ABL. (B) ZAP-70 links phosphorylated TCR and is phosphorylated itself by c-abl. So ZAP-70 can phosphorylate other downstream kinases (SLP-76, LAT) to permit T-cell activation and proliferation. P: phosphate; MHC: major histocompatibility complex; T: T-lymphocyte.