Influence of the Flexible Liposomes on the Skin Deposition of a Hydrophilic Model Drug, Carboxyfluorescein: Dependency on Their Composition

Table 1

Composition of the different types of liposomes and PBS control.

Code	Lipids/components	Particle size (nm)	PDI	zeta potential
CF-CL	Lipoid-S75 10%	115±1.1	0.132±0.004	−12.6±0.6
	Cholesterol 5%
CF-FL1	Lipoid-S75	83±3.2	0.051± 0.003	−26.4± 1.1
	Sodium cholate 2.8%
CF-FL2	Lipoid-S75 10%	133± 1.4	0.083±0.008	−37.4±1.6
	Tween 80 2.8%
CF-FL3	Lipoid-S75 10%	175± 1.2	0.188± 0.025	−65.3± 1.5
	Cineole 1%
	Ethanol 3.3%
PBS control	PBS (pH 7.4)

CF-CL: conventional liposomes; CF-FL1: flexible liposomes containing sodium cholate; CF-FL2: flexible liposomes containing tween 80; CF-FL3: flexible liposomes containing cineole and ethanol; the controls present the PBS solution.