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The Scientific World Journal
Volume 2012, Article ID 158075, 5 pages
http://dx.doi.org/10.1100/2012/158075
Research Article

Predictors of Acquired Perforating Dermatosis in Uremic Patients on Hemodialysis: A Case-Control Study

1Department of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, Taiwan
2College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
3Department of Hepatogastroenterology and Liver Research Unit, Chang Gung Memorial Hospital, Keelung 204, Taiwan
4Department of Pathology, Chang Gung Memorial Hospital, Linkou 333, Taiwan
5Department of Dermatology, Chang Gung Memorial Hospital, Linkou 333, Taiwan

Received 22 October 2012; Accepted 3 December 2012

Academic Editors: E. Haneke, A. Ishida-Yamamoto, K. Krasagakis, T. L. Meinking, and U. Wollina

Copyright © 2012 Cheng-Hao Weng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD). Methods. A case-control study was performed at our outpatient HD center between January 1, 2000 and March 31, 2011. Patients on HD with APD were matched (1 : 2) for gender and age with controls on HD. Conditional logistic regression was used to identify factors associated with APD. Results. A total of 19 patients with APD and 38 age and gender matched patients were enrolled in the study. Univariate logistic regression showed that APD was significantly associated with diabetes mellitus (DM), reduced levels of intact parathyroid hormone (iPTH) and albumin (Alb), reduced dialysis adequacy ( ) and urea reduction rate (URR), and elevated levels of high-sensitivity C-reactive protein (hsCRP). Multivariate logistic regression identified reduced iPTH (hazard ratio (HR): 0.983; ) and Alb (HR: 0.099; ) and elevated hsCRP (HR: 1.210, ) as risk factors for APD. Conclusions. iPTH, hsCRP, and Alb are predictors for APD in HD patients.