The Scientific World Journal

Research Article

In Vitro Synergistic Effect of Psidium guineense (Swartz) in Combination with Antimicrobial Agents against Methicillin-Resistant Staphylococcus aureus Strains

Table 1

MIC/MBC of the aqueous extract of Psidium guineense and antimicrobial agents against MRSA strains.


Staphylococcus aureus	MIC/MBC (μg/mL)
Staphylococcus aureus	AMC	AMP	CEF	CIP	GET	MER	AE	Resistance phenotype¹

ATCC 25923	3.12/6.24	3.12/6.24	3.12/6.24	3.12/6.24	0.39/0.78	3.12/6.24	250/500	Control strain
LFBM 01	25.0/50.0	400/800	400/800	50.0/100	12.5/25.0	25.0/50.0	250/500	AMC, CFO, CIP, GET
LFBM 05	6.25/12.5	100/200	25/50.0	3.12/6.24	3.12/6.24	12.5/25.0	250/500	AMP, AZI, CFO, PEN
LFBM 08	3.12/6.24	100/200	12.5/25.0	3.12/6.24	3.12/6.24	6.25/12.5	250/500	AMP; AZI, CIP, CFO
LFBM 16	12.5/25.0	25.0/50.0	12.5/25.0	3.12/6.24	3.12/6.24	6.25/12.5	250/500	AMP, AZI, CFO, PEN
LFBM 26	50.0/100	400/800	400/800	50.0/100	25.0/50.0	25.0/50.0	250/500	AMC, AMP, CFO, CIP
LFBM 28	25.0/50.0	400/800	100/200	50.0/100	25.0/50.0	12.5/25.0	250/500	AMC, CIP, CFO, GET
LFBM 29	12.5/25.0	50.0/100	25/50.0	3.12/6.24	3.12/6.24	12.5/25.0	500/1000	AMC, AMP, CFO, PEN
LFBM 30	12.5/25.0	200/400	12.5/25.0	50.0/100	3.12/6.24	12.5/25.0	250/500	AMC, AMP, CFO, CIP
LFBM 31	12.5/25.0	100/100	12.5/25.0	50.0/100	3.12/6.24	6.25/12.5	250/500	AMP, AZI, CFO; CIP;
LFBM 32	12.5/25.0	200/200	12.5/25.0	50.0/100	3.12/6.24	12.5/25.0	250/500	AMP, CFO, CIP, PEN
LFBM 33	12.5/25.0	200/200	200/200	50.0/100	3.12/6.24	12.5/25.0	250/500	AMC, AMP, CFO, CIP

MIC: minimal inhibitory concentration; MBC: minimal bactericidal concentration; ATCC: American Type Culture Collection; LFBM: Laboratório de Fisiologia e Bioquímica de Microorganismos; AMC: amoxicillin/clavulanic acid; AMP: ampicillin; AZI: azithromycin; CFO: cefoxitin; CIP: ciprofloxacin; GET: gentamicin; PEN: penicillin; MER: meropenem; AE: aqueous extract of P. guineense.
¹Resistance phenotype determined by the disk-diffusion method.