Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period

Table 4

Use of additional medication.

		Time (month)
		0	2	4	6	12
Medication
NSAID, oral administration	HA	9	8	7	7	5
	Placebo	10	10	7	7	4
NSAID, external use	HA	16	15	15	13	13
	Placebo	18	17	17	14	13
HA, intra-articular injection	HA	6	7	8	7	5
	Placebo	8	6	7	7	6

Numbers of subjects requiring respective treatments are shown.
NSAID: nonsteroidal anti-inflammatory drugs.