Review Article
Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration
Table 2
Selected animal and human therapeutic studies.
| Reference number | Model | Intervention | Outcome |
| [26] | Spinal cord injury in rats | Indomethacin and ibuprofen (COX inhibitors) | Increased functional recovery and axonal regeneration | [28] | Sciatic nerve crush in rats | Celecoxib (COX2 inhibitor) | Improved functional recovery | [38] | Sciatic nerve crush in diabetic rats | PGE1 | Improved axonal regeneration | [37] | Sciatic nerve constriction injury in rats | PGE agonist | Decreased neuronal apoptosis | [35] | Sciatic nerve injury in rats | Alprostadil (PGE) | Decreased injury and improved functional recovery | [34] | Sciatic nerve ischemia-reperfusion injury in rats | Alprostadil | Decreased injury | [69] | Carpal tunnel syndrome. Human clinical trial | Tenoxicam (COX inhibitor) | No beneficial effects compared to placebo |
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