Research Article

Collaboration between HPMC and NaCMC in order to Reach the Polymer Critical Point in Theophylline Hydrophilic Matrices

Table 1

Kinetic parameters for the zero-order, Higuchi, Korsmeyer, and Peppas-Sahlin models calculated for the binary and ternary hydrophilic matrix tablets.

Zero orderHiguchiKorsmeyerPeppas and Sahlin
Batch%w/w Drug%w/w HPMC%w/w NaCMC π‘˜ 0 (%minβˆ’1)r 2b (%minβˆ’1/2)r 2k (%minβˆ’n )nr 2 π‘˜ 𝑑 (%minβˆ’m ) π‘˜ π‘Ÿ (%minβˆ’2m )r 2

10604000.0780.9822.1270.9780.5530.7030.9980.9270.1070.998
14703000.1080.9872.4060.9380.3540.8190.9970.5240.1590.997
17802000.2700.9944.6930.9601.6960.6790.9942.3110.2540.996
19901000.3500.9795.5850.9952.0190.6760.9992.6270.3070.999
6600400.4290.9277.9340.8800.0022.0250.999βˆ’4.5820.970.973
11700300.3290.9926.8040.9610.0581.3050.999βˆ’2.4140.6480.998
15800200.4250.9998.0470.9810.1191.2310.999βˆ’2.4530.781>0.999
18900100.4650.9565.2680.9110.0151.8160.999βˆ’7.4531.8010.985
14010500.1460.9974.3470.9660.061.1390.999βˆ’1.7410.4530.999
24020400.1130.9883.4920.9860.2060.9060.997βˆ’0.4180.3040.998
35010400.1700.9944.7660.9770.1111.0640.997βˆ’1.2350.380.998
45020300.1320.9774.1230.9870.2730.8870.995βˆ’0.0660.2560.995
55030200.1500.9994.2100.9670.0831.097>0.999βˆ’1.1710.3840.999
76010300.1510.9606.2220.8800.0231.2990.988βˆ’1.540.3230.984
86020200.1870.9944.4470.9550.121.0760.998βˆ’0.860.3720.997
96030100.2260.9814.0820.9050.0321.330.998βˆ’2.5010.5560.993
127010200.2860.9976.0700.9770.1561.1080.999βˆ’1.1750.5270.999
137020100.3370.9316.7350.8570.0041.8110.995βˆ’3.880.7750.975
168010100.3400.9787.0230.9420.0851.2470.994βˆ’2.010.6280.992

[ π‘˜ 0 (%minβˆ’1): zero-order constant; b (%minβˆ’1/2): Higuchi’s slope; π‘˜ (%minβˆ’n ): kinetics constant of the Korsmeyer model, 𝑛 : diffusional exponent, π‘˜ 𝑑 : diffusional constant of Peppas and Sahlin model, π‘˜ π‘Ÿ : relaxation constant of Peppas and Sahlin model, m: exponent that depends on the geometric shape of the releasing device through its aspect ratio].