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The Scientific World Journal
Volume 2012 (2012), Article ID 179782, 10 pages
http://dx.doi.org/10.1100/2012/179782
Review Article

Exploring Marine Cyanobacteria for Lead Compounds of Pharmaceutical Importance

Department of Bioinformatics and Biotechnology, International Islamic University Islamabad, Sector H-10, 44000 Islamabad, Pakistan

Received 13 October 2011; Accepted 20 November 2011

Academic Editor: Jean-Marc Sabatier

Copyright © 2012 Bushra Uzair et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. W. Castenholz and J. B. Waterbury, “Cyanobacteria,” in Bergey's Manual of Systematic Bacteriology, vol. 3, pp. 171–179, 1989. View at Google Scholar
  2. A. J. Smith, “Modes of cyanobacterial carbon metabolism,” Annales de Microbiologie, vol. 134B, no. 1, pp. 93–113, 1983. View at Google Scholar · View at Scopus
  3. Y Cohen, B. B. Jrgensen, N. P. Revsbech, and R. Paplawski, “Adaptation to hydrogen sulfide of oxygenic and anoxygenic photosynthesis among cyanobacteria,” Applied and Environmental Microbiology, vol. 51, no. 2, pp. 398–407, 1986. View at Google Scholar
  4. P. Fay, “Oxygen relations of nitrogen fixation in cyanobacteria,” Microbiological Reviews, vol. 56, no. 2, pp. 340–373, 1992. View at Google Scholar · View at Scopus
  5. B. A. Whitton, “Diversity, ecology and taxonomy of the cyanobacteria,” in Photosynthetic Prokaryotes, pp. 1–51, Plenum Press, New York, NY, USA, 1992. View at Google Scholar
  6. N. Tandeau de Marsac and J. Houmard, “Adaptation of cyanobacteria to environmental stimuli: new steps towards molecular mechanisms,” FEMS Microbiology Reviews, vol. 104, no. 1-2, pp. 119–189, 1993. View at Google Scholar · View at Scopus
  7. D. Schwarzer, R. Finking, and M. A. Marahiel, “Nonribosomal peptides: from genes to products,” Natural Product Reports, vol. 20, no. 3, pp. 275–287, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. A. Jordan and L. Wilson, “Microtubules and actin filaments: dynamic targets for cancer chemotherapy,” Current Opinion in Cell Biology, vol. 10, no. 1, pp. 123–130, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. W. H. Gerwick, L. T. Tan, and N. Sitachitta, “Nitrogen-containing metabolites from marine cyanobacteria,” in The Alkaloids: Chemistry and Biology, vol. 57, pp. 75–184, Academic Press, San Diego, Calif, USA, 2001. View at Google Scholar
  10. J. Watanabe, M. Minami, and M. Kobayashi, “Antitumor activity of TZT-1027 (soblidotin),” Anticancer Research, vol. 26, no. 3, pp. 1973–1981, 2006. View at Google Scholar · View at Scopus
  11. A. C. Mita, L. A. Hammond, P. L. Bonate et al., “Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third-generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 days in patients with advanced solid tumors,” Clinical Cancer Research, vol. 12, no. 17, pp. 5207–5215, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. K. M. Blumenthal and A. L. Seibert, “Voltage-gated sodium channel toxins: poisons, probes, and future promise,” Cell Biochemistry and Biophysics, vol. 38, no. 2, pp. 215–237, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. R. H. Reed, L. J. Borowitzka, and M. A. Mackay, “Organic solute accumulation in osmotically stressed cyanobacteria,” FEMS Microbiology Reviews, vol. 39, no. 1-2, pp. 51–56, 1986. View at Google Scholar
  14. A. Dufresne, O. Martin, J. S. David et al., “Unraveling the genomic mosaic of a ubiquitous genus of marine cyanobacteria,” Genome Biology, vol. 9, no. 5, article R90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Raghavan, B. Kadalmani, T. Thirunalasundari, G. Subramanian, and M. A. Akbarsha, Biological and Comparative Endocrinology, Bharathidasan University, Tiruchirapalli, India, 2002.
  16. S. K. Deth, Antimicrobial compounds from marine cyanobacteria with special reference to the bioactivity of a purified compound from Oscillatoria laete-virens BDU 20801, Ph.D. thesis, Bharathidasan University, Thiruchirappalli, India, 1999.
  17. U. S. Euler and R. Eliassen, Prostaglandins, Academic Press, New York, NY, USA, 1967.
  18. D. J. Schaeffer and V. S. Krylov, Anti-HIV Activity of Extracts and Compounds from Algae and Cyanobacteria Department of Veterinary Biosciences, University of Illinois, 2001.
  19. T. Kaneko, A. Tanaka, S. Sato et al., “Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome,” DNA Research, vol. 2, no. 4, pp. 153–166, 1995. View at Google Scholar · View at Scopus
  20. W. H. Gerwick, L. T. Tan, and N. Sitachitta, “Nitrogen-containing metabolites from marine cyanobacteria,” Alkaloids: Chemistry and Biology, vol. 57, pp. 75–184, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Teruya, K. Kobayashi, K. Suenaga, and H. Kigoshi, “Phormidinines A and B, novel 2-alkylpyridine alkaloids from the cyanobacterium Phormidium sp,” Tetrahedron Letters, vol. 46, no. 23, pp. 4001–4003, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. M. A. Orsini, L. K. Pannell, and K. L. Erickson, “Polychlorinated acetamides from the cyanobacterium Microcoleus lyngbyaceus,” Journal of Natural Products, vol. 64, no. 5, pp. 572–577, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. J. C. Meeks, “An overview of the genome of Nostoc punctiforme, a multicellular, symbiotic cyanobacterium,” Current Science, vol. 89, no. 1, 2005. View at Google Scholar
  24. P. Spolaore, C. Joannis-Cassan, E. Duran, and A. Isambert, “Commercial applications of microalgae,” Journal of Bioscience and Bioengineering, vol. 101, no. 2, pp. 87–96, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Lehane and R. J. Lewis, “Ciguatera: recent advances but the risk remains,” International Journal of Food Microbiology, vol. 61, no. 2-3, pp. 91–125, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Shimizu, “Microalgal metabolites,” Current Opinion in Microbiology, vol. 6, no. 3, pp. 236–243, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. S. P. Gunasekera, M. W. Miller, J. C. Kwan, H. Luesch, and V. J. Paul, “Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis,” Journal of Natural Products, vol. 73, no. 3, pp. 459–462, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. J. C. Kwan, K. Taori, V. J. Paul, and H. Luesch, “Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena,” Marine Drugs, vol. 7, no. 4, pp. 528–538, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Radau, “Cyanopeptides: a new and nearly inexhaustible natural resource for the design and structure-activity relationship studies of the new inhibitors of trypsin-like serine proteases,” Current Enzyme Inhibition, vol. 1, pp. 295–307, 2005. View at Google Scholar
  30. K. Taori, S. Matthew, C. Ross, R. R. James, V. J. Paul, and H. Luesch, “Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp,” Journal of Natural Products, vol. 70, no. 10, pp. 1593–1600, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Matthew, C. Ross, V. J. Paul, and H. Luesch, “Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides,” Tetrahedron, vol. 64, no. 18, pp. 4081–4089, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Plaza and C. A. Bewley, “Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria sp,” Journal of Organic Chemistry, vol. 71, no. 18, pp. 6898–6907, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. S. P. Gunasekera, R. Ritson-Williams, and V. J. Paul, “Carriebowmide, a new cyclodepsipeptide from the marine cyanobacterium Lyngbya polychroa,” Journal of Natural Products, vol. 71, no. 12, pp. 2060–2063, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Cruz-Rivera and V. J. Paul, “Chemical deterrence of a cyanobacterial metabolite against generalized and specialized grazers,” Journal of Chemical Ecology, vol. 33, no. 1, pp. 213–217, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. R. W. Thacker, D. G. Nagle, and V. J. Paul, “Effects of repeated exposures to marine cyanobacterial secondary metabolites on feeding by juvenile rabbitfish and parrotfish,” Marine Ecology Progress Series, vol. 147, no. 1–3, pp. 21–29, 1997. View at Google Scholar · View at Scopus
  36. V. J. Paul, R. W. Thacker, K. Banks, and S. Golubic, “Benthic cyanobacterial bloom impacts the reefs of South Florida (Broward County, USA),” Coral Reefs, vol. 24, no. 4, pp. 693–697, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. L. T. Tan, N. Sitachitta, and W. H. Gerwick, “The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula,” Journal of Natural Products, vol. 66, no. 6, pp. 764–771, 2003. View at Google Scholar · View at Scopus
  38. S. Bunyajetpong, W. Y. Yoshida, N. Sitachitta, and K. Kaya, “Trungapeptins A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula,” Journal of Natural Products, vol. 69, no. 11, pp. 1539–1542, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. L. T. Tan, B. L. Márquez, and W. H. Gerwick, “Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii,” Journal of Natural Products, vol. 65, no. 6, pp. 925–928, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. F. Sponga, L. Cavaletti, A. Lazzarini et al., “Biodiversity and potentials of marine-derived microorganisms,” Journal of Biotechnology, vol. 70, no. 1–3, pp. 65–69, 1999. View at Publisher · View at Google Scholar · View at Scopus
  41. A. M. S. Mayer and K. R. Gustafson, “Marine pharmacology in 2000: antitumor and cytotoxic compounds,” International Journal of Cancer, vol. 105, no. 3, pp. 291–299, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. K. E. Fladmark, M. H. Serres, N. L. Larsen, T. Yasumoto, and T. Aune, “Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes,” Toxicon, vol. 36, no. 8, pp. 1101–1114, 1998. View at Publisher · View at Google Scholar · View at Scopus
  43. A. R. Humpage and I. R. Falconer, “Microcystin-LR and liver tumor promotion: effects on cytokinesis, ploidy, and apoptosis in cultured hepatocytes,” Environmental Toxicology, vol. 14, no. 1, pp. 61–75, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. C. Angsuthanasombat and S. Panyim, “Biosynthesis of 130-kilodalton mosquito larvicide in the cyanobacterium Agmenellum quadruplicatum PR-6,” Applied and Environmental Microbiology, vol. 55, no. 9, pp. 2428–2430, 1989. View at Google Scholar · View at Scopus
  45. R. C. Murphy and S. E. Stevens, “Cloning and expression of the cryIVD gene of Bacillus thuringiensis subsp. israelensis in the cyanobacterium Agmenellum quadruplicatum PR-6 and its resulting larvicidal activity,” Applied and Environmental Microbiology, vol. 58, no. 5, pp. 1650–1655, 1992. View at Google Scholar · View at Scopus
  46. B. Soni, U. Trivedi, and D. Madamwar, “A novel method of single step hydrophobic interaction chromatography for the purification of phycocyanin from Phormidium fragile and its characterization for antioxidant property,” Bioresource Technology, vol. 99, no. 1, pp. 188–194, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. G. Francis, “Poisonous Australian lake,” Nature, vol. 18, no. 444, pp. 11–12, 1878. View at Google Scholar · View at Scopus
  48. N. Gupta, S. C. Pant, R. Vijayaraghavan, and P. V. L. Rao, “Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice,” Toxicology, vol. 188, no. 2-3, pp. 285–296, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. I. R. Falconer and A. R. Humpage, “Health risk assessment of cyanobacterial (blue-green algal) toxins in drinking water,” International Journal of Environmental Research and Public Health, vol. 2, no. 1, pp. 43–50, 2005. View at Google Scholar · View at Scopus
  50. K. Vareli, E. Briasoulis, G. Pilidis, and I. Sainis, “Molecular confirmation of Planktothrix rubescens as the cause of intense, microcystin-Synthesizing cyanobacterial bloom in Lake Ziros, Greece,” Harmful Algae, vol. 8, no. 3, pp. 447–453, 2009. View at Publisher · View at Google Scholar · View at Scopus