Angiotensins Inhibit Cell Growth in GH3 Lactosomatotroph Pituitary Tumor Cell Culture: A Possible Involvement of the p44/42 and p38 MAPK Pathways

Figure 2

The influence of aminopeptidases inhibitor amastatin (Ama) at concentrations 10⁻⁷ M, 10⁻⁶ M, and 10⁻⁵ M on angiotensin II (AII)- and angiotensin IV (AIV)-induced decrease of the cellular viability in the lactosomatotroph GH3 cell culture. 𝑋 axis: absolute values of the optical density (OD), auxiliary axis (▲)—OD in the particular groups expressed as the percentage of the optical density measured at 450 nm of unstimulated cells (control (C) = 100%). 𝑋 ± SEM; ***𝑃<0,001 versus C, **𝑃<0,01 versus C, *𝑃<0,05 versus AIV.