Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012 (2012), Article ID 215231, 5 pages
http://dx.doi.org/10.1100/2012/215231
Clinical Study

Prognostic Significance of Serum Proangiogenic Molecules in Patients with De Novo Non-Hodgkin Lymphomas

1Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
2Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand

Received 13 October 2011; Accepted 21 November 2011

Academic Editor: Angelo Guerrasio

Copyright © 2012 Pairaya Rujirojindakul and Arnuparp Lekhakula. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Hanahan and J. Folkman, “Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis,” Cell, vol. 86, no. 3, pp. 353–364, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Folkman, “Angiogenesis in cancer, vascular, rheumatoid and other disease,” Nature Medicine, vol. 1, no. 1, pp. 27–31, 1995. View at Google Scholar · View at Scopus
  3. M. L. Iruela-Arispe and H. F. Dvorak, “Angiogenesis: a dynamic balance of stimulators and inhibitors,” Thrombosis and Haemostasis, vol. 78, no. 1, pp. 672–677, 1997. View at Google Scholar · View at Scopus
  4. K. Podar and K. C. Anderson, “The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications,” Blood, vol. 105, no. 4, pp. 1383–1395, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Vacca, D. Ribatti, L. Roncali et al., “Bone marrow angiogenesis and progression in multiple myeloma,” British Journal of Haematology, vol. 87, no. 3, pp. 503–508, 1994. View at Google Scholar · View at Scopus
  6. A. Vacca, D. Ribatti, M. Presta et al., “Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma,” Blood, vol. 93, no. 9, pp. 3064–3073, 1999. View at Google Scholar · View at Scopus
  7. S. Kumar, T. E. Witzig, A. Dispenzieri et al., “Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma,” Leukemia, vol. 18, no. 3, pp. 624–627, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. R. J. D'Amato, M. S. Loughnan, E. Flynn, and J. Folkman, “Thalidomide is an inhibitor of angiogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 9, pp. 4082–4085, 1994. View at Google Scholar · View at Scopus
  9. J. B. Bartlett, K. Dredge, and A. G. Dalgleish, “The evolution of thalidomide and its IMiD derivatives as anticancer agents,” Nature Reviews Cancer, vol. 4, no. 4, pp. 314–322, 2004. View at Google Scholar · View at Scopus
  10. M. H. Mangi and A. C. Newland, “Angiogenesis and angiogenic mediators in haematological malignancies,” British Journal of Haematology, vol. 111, no. 1, pp. 43–51, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Medinger, N. Fischer, and A. Tzankov, “Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies,” Journal of Oncology, vol. 2010, Article ID 729725, 13 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Salven, L. Teerenhovi, and H. Joensuu, “A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma,” Blood, vol. 90, no. 8, pp. 3167–3172, 1997. View at Google Scholar · View at Scopus
  13. P. Salven, L. Teerenhovi, and H. Joensuu, “A high pretreatment serum basic fibroblast growth factor concentration is an independent predictor of poor prognosis in non-Hodgkin's lymphoma,” Blood, vol. 94, no. 10, pp. 3334–3339, 1999. View at Google Scholar · View at Scopus
  14. P. Salven, A. Orpana, L. Teerenhovi, and H. Joensuu, “Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients,” Blood, vol. 96, no. 12, pp. 3712–3718, 2000. View at Google Scholar · View at Scopus
  15. F. Bertolini, M. Paolucci, F. Peccatori et al., “Angiogenic growth factors and endostatin in non-Hodgkin's lymphoma,” British Journal of Haematology, vol. 106, no. 2, pp. 504–509, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Ribatti, A. Vacca, B. Nico, M. Fanelli, L. Roncali, and F. Dammacco, “Angiogenesis spectrum in the stroma of B-cell non-Hodgkin's lymphomas. An immunohistochemical and ultrastructural study,” European Journal of Haematology, vol. 56, no. 1-2, pp. 45–53, 1996. View at Google Scholar · View at Scopus
  17. E. Crivellato, B. Nico, A. Vacca, and D. Ribatti, “B-cell non-Hodgkin's lymphomas express heterogeneous patterns of neovascularization,” Haematologica, vol. 88, no. 6, pp. 671–678, 2003. View at Google Scholar · View at Scopus
  18. M. Nguyen, H. Watanabe, A. E. Budson, J. P. Richie, D. F. Hayes, and J. Folkman, “Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers,” Journal of the National Cancer Institute, vol. 86, no. 5, pp. 356–361, 1994. View at Google Scholar · View at Scopus
  19. G. Brunner, H. Nguyen, J. Gabrilove, D. B. Rifkin, and E. L. Wilson, “Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells,” Blood, vol. 81, no. 3, pp. 631–638, 1993. View at Google Scholar · View at Scopus
  20. A. Tzankov, S. Heiss, S. Ebner et al., “Angiogenesis in nodal B cell lymphomas: a high throughput study,” Journal of Clinical Pathology, vol. 60, no. 5, pp. 476–482, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. K. N. Ganjoo, A. M. Moore, A. Orazi, J. A. Sen, C. S. Johnson, and C. S. An, “The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: a retrospective study of 97 patients,” Journal of Cancer Research and Clinical Oncology, vol. 134, no. 3, pp. 381–387, 2008. View at Publisher · View at Google Scholar · View at Scopus