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The Scientific World Journal
Volume 2012, Article ID 236427, 4 pages
Research Article

Molecular Markers of Dental Pulp Tissue during Orthodontic Tooth Movement: A Pilot Study

1Department of Orthodontics, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia
2School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Malaysia

Received 1 December 2011; Accepted 30 January 2012

Academic Editors: M. Alexandre Coelho Sinhoreti and J. Veerkamp

Copyright © 2012 Rohaya Megat Abdul Wahab et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Three specific orthodontic tooth movement genes, that is, FCRL1, HSPG2, and LAMB2 were detected at upper first premolar (with appliance) dental pulp tissue by using GeneFishing technique as compared to lower first premolar (without appliance). These three differentially expressed genes have the potential as molecular markers during orthodontic tooth movement by looking at molecular changes of pulp tissue.