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The Scientific World Journal
Volume 2012, Article ID 238494, 6 pages
Clinical Study

Ankle-Brachial Index Is a Powerful Predictor of Renal Outcome and Cardiovascular Events in Patients with Chronic Kidney Disease

1School of Medicine, National Yang-Ming University, No. 155, Section 2, Linong Street, Taipei, Taiwan
2Division of Nephrology, Department of Internal Medicine, National Yang-Ming University Hospital, No. 152, Xinmin Road, Yilan, Taiwan
3Division of Nephrology, Department of Internal Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei, Taiwan
4Department of Nursing, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei, Taiwan

Received 25 September 2011; Accepted 31 October 2011

Academic Editors: A. Bagul, L. Kuller, and J. Luño

Copyright © 2012 Fu-An Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ankle-brachial index (ABI) is an accurate tool to diagnose peripheral arterial disease. The aim of this study was to evaluate whether ABI is also a good predictor of renal outcome and cardiovascular events in patients with chronic kidney disease (CKD). We enrolled 436 patients with stage 3–5 CKD who had not been undergoing dialysis. Patients were stratified into two groups according to the ABI value with a cut point of 0.9. The composite renal outcome, including doubling of serum creatinine level and commencement of dialysis, and the incidence of cardiovascular events were compared between the two groups. After a median follow-up period of 13 months, the lower ABI group had a poorer composite renal outcome ( O R = 2 . 7 1 9 , 𝑃 = 0 . 0 1 5 ) and a higher incidence of cardiovascular events ( O R = 3 . 2 6 0 , 𝑃 = 0 . 0 0 1 ). Our findings illustrated that ABI is a powerful predictor of cardiovascular events and renal outcome in patients with CKD.