The Study of Release of Chlorhexidine from Preparations with Modified Thermosensitive Poly-N-isopropylacrylamide Microspheres

Table 2

Linear regression coefficients for the assessed release of CX from the polymeric preparations, assuming first-order process.

Release rates	Release rates assessed at 22°C (min^−1)		Release rates assessed at 37°C (min^−1)
Preparation	1st stage	2nd stage	1st stage	2nd stage
pNIPAM-A-CX	0.9737	0.9864	0.9897	0.9675
pNIPAM-B-CX	0.9780	0.9783	0.9941	0.9967
pNIPAM-C-CX	0.9670	0.9584	0.9823	0.9960
MC-CX	0.9884	—	0.9838	—
PA-CX	0.8585	—	0.6922	—
H2O-CX	0.9949	—	0.9761	—

pNIPAM-A-CX, pNIPAM-B-CX, pNIPAM-C-CX: preparations of respective polymers detailed in the text with chlorhexidine, MC-CX: preparation of methylcellulose and chlorhexidine, PA-CX: preparation of polyacrylic acid and chlorhexidine, and H₂O-CX: aqueous dispersion of chlorhexidine, data from repeated six experiments.