LDL-Apheresis: Technical and Clinical Aspects

Table 1

Extracorporeal methods for elimination of LDL cholesterol [1].

Year	Authors	Method	Advantage	Disadvantage
1967	De Gennes et al. [2]	Plasmapheresis	Quick and well-tolerated elimination of pathologic substances	Unselectivity, danger of infection, bleeding, and risks of human albumin
1975	Thompson et al. [3]	Plasmapheresis
1980	Agishi et al. [4]	Cascade filtration	Semiselectivity	Danger of infection and low effectiveness
1981	Stoffel and Demant [5]	Immunoadsorption	Selectivity, effectiveness, regeneration, and reusability	Expensive technology
1983	Borberg et al. [6]	Immunoadsorption
1983	Wieland and Seidel [7]	Heparin-induced LDL precipitation (HELP)	Selectivity and effectiveness	Expensive technology
1985	Nose et al. [8]	Thermofiltration	Selectivity and effectiveness	Outdated technology, behavior of macromolecules under heat unknown and not available
1985	Antwiller et al. [9]	Dextransulfate-induced LDL precipitation	Selectivity and effectiveness	Expensive technology and not available
1987	Mabuchi et al. [10]	Dextransulfate LDL adsorption (liposorber-LA 15)	Selectivity and effectiveness	Expensive technology
1993	Bosch et al. [11]	LDL hemoperfusion (DALI)	Selectivity, effectiveness, and simple technology	Unknown
2003	Otto et al. [12]	LDL hemoperfusion (liposorber D)	Selectivity, effectiveness, and simple technology	Unknown