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The Scientific World Journal
Volume 2012, Article ID 356128, 6 pages
Research Article

Prognostic Value of Hepatocyte Growth Factor, Syndecan-1, and Osteopontin in Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance

1Department of Internal Medicine III, Palacky University and University Hospital Olomouc, 775 20 Olomouc, Czech Republic
2Department of Clinical Biochemistry, Palacky University and University Hospital Olomouc, 775 20 Olomouc, Czech Republic
3Department of Biophysics and Statistics, Palacky University of Olomouc, 775 20 Olomouc, Czech Republic

Received 29 October 2011; Accepted 1 December 2011

Academic Editors: M. Borset and D. H. Dinh

Copyright © 2012 Jiri Minarik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Our aim was to compare serum levels of selected biological parameters in different phases of multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) to determine their diagnostic and prognostic potential. A cohort of 234 individuals was assessed for serum levels of hepatocyte growth factor (HGF), syndecan-1/CD138 (SYN), and osteopontin (OPN). The patients with MM ( 𝑁 = 1 5 6 ) were divided into 3 groups: at the time of diagnosis ( 𝑁 = 4 5 ), in relapse/progression ( 𝑁 = 5 6 ), and in remission ( 𝑁 = 5 0 ). The analysis revealed significant differences of all three parameters in comparison of active and remission phase MM. Moreover, the parameters in active myeloma were significantly higher than in MGUS. Within the comparison of active disease (newly diagnosed and relapsing), there was no significant difference. Similar results were in remission phase MM and MGUS. There was no relationship of pretreatment levels of the parameters to therapeutic response. We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM. The levels of all three parameters behave accordingly with MM activity. Pretreatment measurement without the assessment of their kinetics, however, has no relationship to therapeutic response.