Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012, Article ID 372972, 6 pages
Research Article

Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry

1Department of Orthopaedics, Ulin General Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70232, Indonesia
2Department of Biology, Faculty of Science, Brawijaya University, Malang 65145, Indonesia
3Department of Orthopaedics, Syaiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang 65122, Indonesia
4Department of Orthopaedics, Hasan Sadikin Hospital, Faculty of Medicine, Padjadjaran University, Bandung 40161, Indonesia
5Department of Chemistry, Faculty of Science, Brawijaya University, Malang 65145, Indonesia
6Division of Nanomaterial Sciences, EcoTopia Science Institute, Nagoya University, Nagoya 464-8603, Japan

Received 31 October 2011; Accepted 25 December 2011

Academic Editor: Jameela Banu

Copyright © 2012 Zairin Noor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Clinical research indicates that negative calcium balance is associated with low bone mass, rapid bone loss, and high fracture rates. However, some studies revealed that not only calcium is involved in bone strengthening as risk factor of fracture osteoporosis. Thus, in this report, the difference of metallic and nonmetallic elements in osteoporosis and normal bones was studied by high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS). The influence of these elements on bone metabolic processes is also discussed. Inclusion criteria of bone samples consist of postmenopausal woman, trabecular bone fracture, normal and osteoporosis BMD value, and no history of previous disease. The results showed that the concentration of B, Al, S, V, Co, Mo, Te, Ba, La, Ni, As, and Ca/P ratio is higher in osteoporosis than normal. These atomic minerals have negative role to imbalance between bone resorption and bone formation activity. Conversely, concentrations of Na, Mg, P, K, Ca, Cr, Pd, Ag, Mn, Fe, Cu, Zn, Rb, Sr, Pb, and Se are lower in osteoporosis than in normal bones. Among these atoms, known to have important roles in bone structure, we found involvement of atomic mineral and calcium which are considerable to contribute to osteoporotic phenomena.