Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model

Table 2

Effect of MnTE-2-PyP on the activity of some enzymes of lung antioxidant defence system in mice asthma model.

28 day after treatment (48 hours after the last inhalation)
Parameters	Groups
	Control	OVA	MnTE-2-PyP	OVA + MnTE-2-PyP
SOD activity in U/g	31.1±1.79	22.1±1.94 *	28.6±1.01	28.6±1.25^†
mean ± SEM
CAT activity in mcat/g	38.14	29.48*	35.91	34.81^†
Median (min–max)	(33.08–44.12)	(21.51–31.20)	31.92–38.72	31.69–43.51
Q3–Q1	5.07	4.30	4.5	9.14
GP activity in U/g	111.2	76.07*	115.3	101.5
Median (min–max)	51.4–138.74	66.85–83.56	100.7–118.25	62.27–136.92
Q3–Q1	29.65	6.38	12.74	49.81
NPSH groups in mol/g 10^−7	0.58±0.03	0.40±0.03 *	0.54±0.084	0.55±0.04^†
mean ± SEM

OVA: ovalbumin; MnTE-2-PyP: Manganese (III) 5,10,15,20-tetrakis (N-ethylpyridinium-2-yl) porphyrin; SOD: superoxide dismutase; CAT: catalase; GP: glutathion peroxidase; NPSH groups: non protein sulfhydryl groups; SEM, standard error of mean; Q₃–Q₁: interquartile range
*Different from control at 𝑃<0.05;
^†Different from group 2 (OVA) at 𝑃<0.05.