Different Modulating Effects of Adenosine on Neonatal and Adult Polymorphonuclear Leukocytes
Figure 1
The modulating effects of adenosine on adhesion molecule expressions of neonatal and adult PMNs. (a) Cord blood PMNs always had a lower CD11b expression than adult PMNs upon fMLP stimulation. The results presented are representative of 6 duplicate experiments. (b) Plots illustrate CD11b expression levels (expressed as GEOMEAN % relative to adenosine 0 μM in the ordinate) of adult and cord blood PMNs. Both in adult and cord blood PMNs, the signal intensities of CD11b were about nine percent decreased with an adenosine concentration of 1 μM (compared with adenosine 0 μM). Data are expressed as mean ± SD. adenosine 0 μM versus adenosine 1 μM and adenosine 0 μM versus adenosine 10 μM. Abbreviations: AB PMNs: adult peripheral blood polymorphonuclear cells; CB PMNs: cord blood polymorphonuclear cells. Data presented are calculated from 6 duplicate experiments.
