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The Scientific World Journal
Volume 2012, Article ID 390613, 6 pages
Research Article

Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats

1Department of Physiology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia
2Department of Pathology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia
3Department of Biochemistry, Faculty of Medicine, University of Nis, 18000 Nis, Serbia
4Department of Pharmacology, Faculty of Medicine, University of Nis, 18000 Nis, Serbia

Received 27 October 2011; Accepted 22 December 2011

Academic Editor: Paolo Caraceni

Copyright © 2012 Pavle Randjelovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine potential beneficial effects of SA coadministration with gentamicin. Gentamicin was observed to cause a severe nephrotoxicity which was evidenced by an elevation of serum urea and creatinine levels. The significant increases in malondialdehyde (MDA) levels and protein carbonyl groups indicated that GM-induced tissue injury was mediated through oxidative reactions. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GM treatment. Exposure to GM caused necrosis of tubular epithelial cells. Necrosis of tubules was found to be prevented by SA pretreatment. The results from our study indicate that SA supplement attenuates oxidative-stress associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.