|
| Study | Injury type/animal model | Cellular type/factor | Major findings |
|
| McKenzie et al. [33] | Sciatic nerve crush injury in myelin-deficient mice | Skin-derived precursors differentiated into Schwann cells | Remyelination and functional recovery |
| Udina et al. [34] | Sciatic nerve injury in mice (0.6 cm gap) | Collagen guides seeded with allogeneic Schwann cells plus FK-506 | Successful regeneration and functional recovery |
| Negishi et al. [11] | Optic nerve injury in rats (transection) | Extracellular matrix Schwann cells and neurotrophins | Axonal regeneration of retinal ganglion cells |
| Reid et al. [35] | Sciatic nerve injury in rats (1.0 cm gap) | Adipose-derived stem cells | Dorsal root ganglia protection from apoptosis |
| di Summa et al. [36] | Sciatic nerve injury in rats (1.0 cm gap) | Nerve fibrin conduits seeded with adipose-derived stem cells | Enhanced peripheral nerve repair |
| Evans et al. [37] | Sciatic nerve injury in rats (1.2 cm gap) | Biosynthetic conduits seeded with Schwann cells | Increased nerve regeneration |
| Koshimune et al. [38] | Sciatic nerve injury in rats (1.2 cm gap) | Bioabsorbable Schwann cell-coated conduits | Axonal regeneration |
| Ladak et al. [39] | Sciatic nerve injury in rats (1.2 cm gap) | Bone marrow MSCs differentiated into Schwann-like cells seeded in collagen conduits | Regeneration of sciatic motoneuron |
| Kokai et al. [40] | Sciatic nerve injury in rats (1.5 cm gap) | Scaffolds containing GDNF microparticles | Increased rate of nerve regeneration; migration and proliferation of Schwann cells |
| Dezawa et al. [41] | Sciatic nerve injury in rats (1.5 cm gap) | Bone marrow MSCs differentiated into Schwann-like cells suspended in Matrigel injected into hollow fibers | Successful nerve regeneration and myelination |
| Marchesi et al. [42] | Sciatic nerve injury in rats (1.6 cm gap) | Guides filled with skin-derived stem cells | Functional recovery and myelination |
| Ansselin et al. [43] | Sciatic nerve injury in rats (1.8 cm gap) | Nerve guides filled with syngeneic Schwann cells | Successful nerve regeneration conditional to number of cells implanted |
| May et al. [5] | Cavernous nerves sections in rats (0.5 cm gap) | Silicon tubes seeded with GDNF-transduced Schwann cells | Increased recovery of erectile function |
| Sun et al. [44] | Facial nerve injury in rats (0.8 cm gap) | Decellularized artery allografts with autologous adipose-derived stem cells | Nerve repair and functional recovery |
| Wang et al. [10] | Facial nerve injury in rabbits (1.0 cm gap) | Autologous vein graft filled with autologous MSCs differentiated into Schwann cells | Improvement of functional recovery and upregulated myelin mRNA |
| Cheng and Chen [45] | Sciatic nerve injury in rabbits (2.0 cm gap) | Polyglactin scaffolds seeded with Schwann cells and coated with biomembranes | Successful nerve regeneration |
| Zhang et al. [46] | Tibial nerve injury in rabbits (4.0 cm gap) | Autogenous venous graft filled with Schwann cells | Successful nerve regeneration and electromyographic improvement |
| Wakao et al. [47] | Non-human primates median nerve injury (2.0 cm gap) | Collagen guides seeded with bone marrow MSC-derived Schwann cells | Functional, histological, and electromyographical recovery |
| Hu et al. [31] | Non-human primates ulnar nerve injury (4.0 cm gap) | Acellular allogeneic nerve grafts with autologous MSCs | Structural and functional peripheral nerve repair |
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