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The Scientific World Journal
Volume 2012, Article ID 414797, 5 pages
http://dx.doi.org/10.1100/2012/414797
Clinical Study

Lack of Association of Childhood Partial Epilepsy with Brain Derived Neurotrophic Factor Gene

1Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Montro, Izmir, Turkey
2Department of Medical Genetics, Faculty of Medicine, Dokuz Eylul University, Balcova, 35340 Izmir, Turkey
3Department of Pediatrics, Division of Genetics, Dokuz Eylul University, Balcova, 35340 Izmir, Turkey

Received 11 October 2011; Accepted 30 November 2011

Academic Editors: D. J. Moore and T. Niu

Copyright © 2012 Aycan Unalp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Brain-derived factor (BDNF) is a member of neurotrophin family and is localized and upregulated in areas implicated in epileptogenesis. Several lines of evidence make the BDNF gene a plausible candidate gene for predisposition to epilepsy. In this study, we tested that BDNF might be involved in the etiology of childhood PE. To assess whether BDNF gene C270T polimorphism could be implicated in vulnerability to PE, we conducted a case-control association analysis (112 partial epileptic and 100 controls) in Turkish children. Epileptic children were divided into two groups: 1—idiopathic ( 𝑛 = 8 5 ) and 2—symptomathic epilepsy ( 𝑛 = 2 7 ). There was no significant difference in genotypic distribution and allelic frequencies of the BDNF gene C270T polimorphism between the PE and control groups. However, the BDNF gene TT genotype was more frequently seen in the epileptic children (15 versus 11 patients, resp.). Interestingly, in the epilepsy group, both two children with TT genotype have posttraumatic epilepsy. The data indicate a possible association with the 270T genotype of the BDNF gene with a posttraumatic epilepsy. To draw any conclusion, further studies using larger sample sizes should be carried out in various ethnic populations in childhood epilepsies.