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The Scientific World Journal
Volume 2012 (2012), Article ID 420763, 3 pages
Clinical Study

Umbilical Cord Serum Erythropoietin Levels and Maternal Smoking in Pregnancy

1Department of Pediatrics, Vakif Gureba Teaching and Training Hospital, Istanbul, Turkey
2Department of Pediatrics, American Hospital, Istanbul, Turkey

Received 27 October 2011; Accepted 11 December 2011

Academic Editors: Y. Asano and J. Luño

Copyright © 2012 Soner Sazak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the effect of maternal smoking during pregnancy on levels of umbilical cord erythropoietin. Methods. Erythropoietin levels were measured in umbilical cord sera of 60 newborns who were delivered vaginally at term. There were 20 (33%) smoking and 40 (67%) nonsmoking mothers. Results. Mean cord serum erythropoietin levels were significantly lower in the nonsmokers (nonsmokers, 24 ± 9 IU/L; smokers, 61 ± 46 IU/L; 𝑃 < . 0 0 1 ). There was a significant positive correlation between the number of cigarettes smoked per day and cord serum erythropoietin levels ( π‘Ÿ , 0.58; 𝑃 ≀ . 0 5 ). Conclusions. Smoking during pregnancy is associated with increased levels of umbilical cord erythropoietin at birth. This may indicate a risk of fetal hypoxia and growth restriction. Education and encouragement of cessation of smoking during pregnancy are important to avoid associated fetal and maternal morbidity and mortality.