Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2012 (2012), Article ID 439479, 9 pages
http://dx.doi.org/10.1100/2012/439479
Research Article

Autophagic Cell Death Is Induced by Acetone and Ethyl Acetate Extracts from Eupatorium odoratum In Vitro: Effects on MCF-7 and Vero Cell Lines

1Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
2School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia

Received 23 October 2011; Accepted 19 December 2011

Academic Editor: Julie Gavard

Copyright © 2012 Faizah Bt. Harun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. C. Ong and J. Norzalina, “Malay herbal medicine in Gemencheh, Negri Sembilan, Malaysia,” Fitoterapia, vol. 70, no. 1, pp. 10–14, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. H. C. Ong and M. Nordiana, “Malay ethno-medico botany in Machang, Kelantan, Malaysia,” Fitoterapia, vol. 70, no. 5, pp. 502–513, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. A. N. Hisham and C. H. Yip, “Overview of breast cancer in Malaysian women: a problem with late diagnosis,” Asian Journal of Surgery, vol. 27, no. 2, pp. 130–133, 2004. View at Google Scholar · View at Scopus
  4. J. Bange, E. Zwick, and A. Ullrich, “Molecular targets for breast cancer therapy and prevention,” Nature Medicine, vol. 7, no. 5, pp. 548–552, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. L. F. Díaz, M. Chiong, A. F. G. Quest, S. Lavandero, and A. Stutzin, “Mechanisms of cell death: molecular insights and therapeutic perspectives,” Cell Death and Differentiation, vol. 12, no. 11, pp. 1449–1456, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. R. J. Bold, P. M. Termuhlen, and D. J. McConkey, “Apoptosis, cancer and cancer therapy,” Surgical Oncology, vol. 6, no. 3, pp. 133–142, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. C. C. Hung, E. J. Davison, P. A. Robinson, and H. C. Ardley, “The aggravating role of the ubiquitin-proteasome system in neurodegenerative disease,” Biochemical Society Transactions, vol. 34, no. 5, pp. 743–745, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Levine and G. Kroemer, “Autophagy in the pathogenesis of disease,” Cell, vol. 132, no. 1, pp. 27–42, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Kondo, T. Kanzawa, R. Sawaya, and S. Kondo, “The role of autophagy in cancer development and response to therapy,” Nature Reviews Cancer, vol. 5, no. 9, pp. 726–734, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. W. O. Anthony Jr., L. Tan, A. E. Boitano, D. R. Sorenson, A. Aurora, and J. R. Liu, “Resveratrol-induced autophagocytosis in ovarian cancer cells,” Cancer Research, vol. 64, no. 2, pp. 696–703, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Meschini, M. Condello, M. Marra, G. Formisano, E. Federici, and G. Arancia, “Autophagy-mediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells,” Toxicology in Vitro, vol. 21, no. 2, pp. 197–203, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Suksamrarn, A. Chotipong, T. Suavansri et al., “Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata,” Archives of Pharmacal Research, vol. 27, no. 5, pp. 507–511, 2004. View at Google Scholar · View at Scopus
  13. K. Srinivasa Rao, P. K. Chaudhury, and A. Pradhan, “Evaluation of anti-oxidant activities and total phenolic content of Chromolaena odorata,” Food and Chemical Toxicology, vol. 48, no. 2, pp. 729–732, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. M. Hassan and H. R. Ghareib, “Bioactivity of Ulva lactuca L. acetone extract on germination and growth of lettuce and tomato plants,” African Journal of Biotechnology, vol. 8, no. 16, pp. 3832–3838, 2009. View at Google Scholar · View at Scopus
  15. A. H. Gilani and Atta-ur-Rahman, “Trends in ethnopharmacology,” Journal of Ethnopharmacology, vol. 100, no. 1-2, pp. 43–49, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Dai and R. J. Mumper, “Plant phenolics: extraction, analysis and their antioxidant and anticancer properties,” Molecules, vol. 15, no. 10, pp. 7313–7352, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Yuan, J. Yang, and J. Miao, “Chemical constituents of Eupatorium odoratum,” Chinese Traditional and Herbal Drugs, vol. 36, no. 12, article 1771, 2005. View at Google Scholar
  18. P. K. Bose, P. Chakrabarti, S. Chakravarti, S. P. Dutta, and A. K. Barua, “Flavonoid constituents of Eupatorium odoratum,” Phytochemistry, vol. 12, no. 3, pp. 667–668, 1973. View at Google Scholar · View at Scopus
  19. M. S. Owolabi, A. Ogundajo, K. O. Yusuf et al., “Chemical composition and bioactivity of the essential oil of Chromolaena odorata from Nigeria,” Records of Natural Products, vol. 4, no. 1, pp. 72–78, 2010. View at Google Scholar · View at Scopus
  20. M. Salucci, L. A. Stivala, G. Maiani, R. Bugianesi, and V. Vannini, “Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2),” British Journal of Cancer, vol. 86, no. 10, pp. 1645–1651, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Ishiguro, T. Ando, O. Maeda et al., “Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms,” Biochemical and Biophysical Research Communications, vol. 362, no. 1, pp. 218–223, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. X. H. Yang, T. L. Sladek, X. Liu, B. R. Butler, C. J. Froelich, and A. D. Thor, “Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis,” Cancer Research, vol. 61, no. 1, pp. 348–354, 2001. View at Google Scholar · View at Scopus
  23. B. Fazi, W. Bursch, G. M. Fimia et al., “Fenretinide induces autophagic cell death in caspase-defective breast cancer cells,” Autophagy, vol. 4, no. 4, pp. 435–441, 2008. View at Google Scholar · View at Scopus
  24. H. Rodriguez-Rocha, A. Garcia-Garcia, M. I. Panayiotidis, and R. Franco, “DNA damage and autophagy,” Mutation Research, vol. 711, no. 1-2, pp. 158–166, 2011. View at Publisher · View at Google Scholar
  25. M. J. Abedin, D. Wang, M. A. McDonnell, U. Lehmann, and A. Kelekar, “Autophagy delays apoptotic death in breast cancer cells following DNA damage,” Cell Death and Differentiation, vol. 14, no. 3, pp. 500–510, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. Q. Cui, S.-I. Tashiro, S. Onodera, M. Minami, and T. Ikejima, “Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells,” Biological and Pharmaceutical Bulletin, vol. 30, no. 5, pp. 859–864, 2007. View at Publisher · View at Google Scholar
  27. J. J. Lum, D. E. Bauer, M. Kong et al., “Growth factor regulation of autophagy and cell survival in the absence of apoptosis,” Cell, vol. 120, no. 2, pp. 237–248, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Liang, S. H. Shao, Z. X. Xu et al., “The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis,” Nature Cell Biology, vol. 9, no. 2, pp. 218–224, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Tasdemir, M. C. Maiuri, N. Tajeddine et al., “Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy,” Cell Cycle, vol. 6, no. 18, pp. 2263–2267, 2007. View at Google Scholar · View at Scopus
  30. E. Tasdemir, M. C. Maiuri, L. Galluzzi et al., “Regulation of autophagy by cytoplasmic p53,” Nature Cell Biology, vol. 10, no. 6, pp. 676–687, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. P. L. Kuo, Y. L. Hsu, and C. Y. Cho, “Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells,” Molecular Cancer Therapeutics, vol. 5, no. 12, pp. 3209–3221, 2006. View at Publisher · View at Google Scholar · View at Scopus