Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis

Figure 1

Classification of CFTR mutations. CFTR mutations are classified into six classes according to their effect on CFTR function. Class I mutations inhibit biosynthesis, while Class II mutations affect protein processing. Milder mutations such as Class III, IV, and VI impair CFTR channel function and Class V mutations affect gene expression, adapted from Allen (1999) [8].