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The Scientific World Journal
Volume 2012, Article ID 485758, 5 pages
http://dx.doi.org/10.1100/2012/485758
Research Article

Sonographic Gallbladder Abnormality Is Associated with Intravenous Immunoglobulin Resistance in Kawasaki Disease

1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
2Department of Medical Research and Pediatrics, Show Chwan Memorial Hospital in Chang Bing, Changhua, Taiwan
3School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
4Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
5Department of Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan

Received 13 March 2012; Accepted 14 April 2012

Academic Editors: E. Borda, J. E. Fewell, R. Gorodischer, J. M. Saavedra, and L. Shek

Copyright © 2012 Chih-Jen Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Kawasaki disease (KD) is an acute systematic vasculitis in children which causes coronary arterial lesions and hydrops of gallbladder. Our objective is to correlate the clinical significance and influence on disease outcome of patients with gallbladder abnormalities in Kawasaki dissease. Methods. Children who met KD diagnosis criteria and were admitted for IVIG treatment were retrospectively enrolled for analysis. Patients with abdominal sonography were divided into 2 groups based on the absence (Group A, 𝑁 = 6 1 ) or presence (Group B, 𝑁 = 1 6 ) of gallbladder abnormalities (GBA), defined as hydrops or acalculous cholecystitis. Between the two groups, clinical features, demographic data (including admission days, coronary artery lesions, IVIG resistance), and laboratory data before/after IVIG treatment were collected for analysis. Results. The presence of sonographic gallbladder abnormalities is correlated with higher levels of serum CRP, GPT, and neutrophils. It also points to an increased number of IVIG resistance rates in group B. There was no significant statistical difference among clinical features, age, gender, admission days, or coronary artery lesions between the two groups. Conclusion. Sonographic gallbladder abnormalities are associated with higher CRP, GPT, neutrophil and IVIG resistance in KD. It can be used as a predictor of IVIG resistance in patients with KD.