TY - JOUR
A2 - Burns, K. D.
A2 - Furuichi, K.
AU - Hung, Kuo-Chin
AU - Huang, Chung-Yu
AU - Liu, Chuan-Chieh
AU - Wu, Chih-Jen
AU - Chen, Shao-Yuan
AU - Chu, Pauling
AU - Wu, Chia-Chao
AU - Lo, Lan
AU - Diang, Liang-Kuang
AU - Lu, Kuo-Cheng
PY - 2012
DA - 2012/07/31
TI - Serum Bone Resorption Markers after Parathyroidectomy for Renal Hyperparathyroidism: Correlation Analyses for the Cross-Linked N-telopeptide of Collagen I and Tartrate-Resistant Acid Phosphatase
SP - 503945
VL - 2012
AB - Patients on long-term dialysis may develop secondary hyperparathyroidism (SHPT) with increased serum concentrations of bone resorption markers such as the cross-linked N-telopeptide of type I collagen (NTX) and type-5b tartrate-resistant acid phosphatase (TRAP). When SHPT proves refractory to treatment, parathyroidectomy (PTX) may be needed. Renal patients on maintenance HD who received PTX for refractory SHPT (n=23) or who did not develop refractory SHPT (control subjects; n=25) were followed prospectively for 4 weeks. Serum intact parathyroid hormone (iPTH), NTX, TRAP, and bone alkaline phosphatase (BAP) concentrations were measured serially and correlation analyses were performed. iPTH values decreased rapidly and dramatically. BAP values increased progressively with peak increases observed at 2 weeks after surgery. NTX and TRAP values decreased concurrently and progressively through 4 weeks following PTX. A significant correlation between TRAP and NTX values was observed before PTX but not at 4 weeks after PTX. Additionally, the fractional changes in serum TRAP were larger than those in serum NTX at all times examined after PTX. Serum iPTH, TRAP, and NTX values declined rapidly following PTX for SHPT. Serum TRAP values declined to greater degrees than serum NTX values throughout the 4-week period following PTX.
SN - 2356-6140
UR - https://doi.org/10.1100/2012/503945
DO - 10.1100/2012/503945
JF - The Scientific World Journal
PB - The Scientific World Journal
KW -
ER -