Serum Bone Resorption Markers after Parathyroidectomy for Renal Hyperparathyroidism: Correlation Analyses for the Cross-Linked N-telopeptide of Collagen I and Tartrate-Resistant Acid Phosphatase

Table 1

Clinical variables and biochemical parameters for the control group and for the parathyroidectomy (PTX) group before and 4 weeks after the surgery.

	PTX (𝑛=23)		Control (𝑛=25)
Age, y	49.3 ± 10.8		49.6 ± 11.4
Gender (M/F)	11/12		12/13
HD duration	70.1 ± 21.9 months		68.7 ± 19.3 months
1,25(OH)2 vitamin D3	2.0 μg/day		(—)
	D0	W4	D0	W4
iPTH, pg/mL	1293.3 ± 591.9^b	38.2 ± 23.6^d	189.4 ± 75.2^f	192.4 ± 87.4^f
NTX, (nM BCE/L)	1227.3 ± 458.8^a	679.1 ± 307.2^d	784.1 ± 325.6	769.4 ± 319.6^e
TRAP, U/L	8.87 ± 5.27^b	2.81 ± 0.61^d	2.24 ± 0.65^f	2.19 ± 0.67^f
BAP, U/L	158.6 ± 71.2^b	152.6 ± 53.6^d	26.5 ± 8.4^f	27.4 ± 9.1^f
TCa, mg/dL	10.89 ± 0.86^b	8.52 ± 0.54^c	9.5 ± 0.6^e	9.6 ± 0.6^f
Pi, mg/dL	6.10 ± 0.48^a	2.95 ± 0.77^d	4.9 ± 0.5^f	5.0 ± 0.6^f
Albumin, g/dL	3.91 ± 0.36	3.98 ± 0.33	3.95 ± 0.37	3.96 ± 0.36
FC, %
iPTH		−96.92 ± 1.90		1.58 ± 16.22
NTX		−44.43 ± 11.02		3.40 ± 8.33
TRAP		−61.76 ± 13.84		−2.23 ± 3.08
BAP		−0.75 ± 17.04		−1.87 ± 1.84

^a𝑃<0.05, ^b𝑃<0.01, compared with control group at D0; ^c𝑃<0.05, ^d𝑃<0.01, compared with PTX group at D0; ^e𝑃<0.05, ^f𝑃<0.01, compared with PTX group at W4, Abbreviations: BCE, bone collagen equivalents; BAP, bone alkaline phosphatase; D0, Day 0, before performance of PTX; HD, hemodialysis; W4, 4 weeks after PTX; iPTH, intact parathyroid hormone; NTX, cross-linked N-telopeptide of type I collagen; PTX, parathyroidectomy; Pi, inorganic phosphate; TCa, total calcium; TRAP, tartrate-resistant acid phosphatase 5b; FC: fractional change (%) in marker value between D0 and W4.