Alfa-Lipoic Acid Controls Tumor Growth and Modulates Hepatic Redox State in Ehrlich-Ascites-Carcinoma-Bearing Mice

Table 5

Activities of superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST) (as well as levels of glutathione, GSH, total thiols (T-SH)) in liver of different animal groups.

Parameters	Control	LA	EAC	EAC + LA
SOD (% inhibition)	8.5 ± 0.22	8.5 ± 0.16	77.6 ± 3.1^a	29.7 ± 1.2^ab
CAT (μmol H2O2/sec/g protein)	6.3 ± 0.18	5.9 ± 0.34	2.4 ± 0.22^a	5.1 ± 0.15^ab
GST μmol/min/g protein)	0.48 ± 0.01	0.59 ± 0.01^a	0.19 ± 0.005^a	0.42 ± 0.008^a
GSH (mg GSH/g protein)	0.40 ± 0.005	0.51 ± 0.001^a	0.11 ± 0.004^a	0.27 ± 0.007^ab
T-SH (μg/mg protein)	18.4 ± 0.32	25.4 ± 0.26^a	8.2 ± 0.5^a	14.8 ± 0.3^ab

Values expressed as mean ± SE
^aSignificant at (𝑃<0.05) as compared with control group
^bSignificant at (𝑃<0.05) as compared with EAC group.