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The Scientific World Journal
Volume 2012, Article ID 510149, 8 pages
http://dx.doi.org/10.1100/2012/510149
Research Article

Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes

1Departamento de Reproducción Animal, INIA, 28040 Madrid, Spain
2Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, UCM, 28040 Madrid, Spain
3Departamento de Producción Animal, Facultad de Veterinaria, UCM, 28040 Madrid, Spain
4Departamento de Mejora Genetica Animal, INIA, 28040 Madrid, Spain

Received 30 October 2011; Accepted 22 December 2011

Academic Editors: M. Lavitrano, H. Omoe, D. Yoo, and B. I. Yoon

Copyright © 2012 L. Torres-Rovira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [37 citations]

The following is the list of published articles that have cited the current article.

  • A. Gonzalez-Bulnes, C. Ovilo, C. J. Lopez-Bote, S. Astiz, M. Ayuso, M. L. Perez-Solana, R. Sanchez-Sanchez, and L. Torres-Rovira, “Gender-specific early postnatal catch-up growth after intrauterine growth retardation by food restriction in swine with obesity/leptin resistance,” Reproduction, vol. 144, no. 2, pp. 269–278, 2012. View at Publisher · View at Google Scholar
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  • A. Barbero, S. Astiz, C. Ovilo, C. J. Lopez-Bote, M. L. Perez-Solana, M. Ayuso, I. Garcia-Real, and A. Gonzalez-Bulnes, “Prenatal programming of obesity in a swine model of leptin resistance: modulatory effects of controlled postnatal nutrition and exercise,” Journal of Developmental Origins of Health and Disease, vol. 5, no. 3, pp. 248–258, 2014. View at Publisher · View at Google Scholar
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  • Cristina Ovilo, Antonio Gonzalez-Bulnes, Rita Benitez, Miriam Ayuso, Alicia Barbero, Maria L. Perez-Solana, Carmen Barragan, Susana Astiz, Almudena Fernandez, and Clemente Lopez-Bote, “Prenatal programming in an obese swine model: sex-related effects of maternal energy restriction on morphology, metabolism and hypothalamic gene expression,” British Journal of Nutrition, vol. 111, no. 4, pp. 735–746, 2014. View at Publisher · View at Google Scholar
  • Antonio Gonzalez-Bulnes, Susana Astiz, Cristina Ovilo, Clemente J. Lopez-Bote, Raul Sanchez-Sanchez, Maria L. Perez-Solana, Laura Torres-Rovira, Miriam Ayuso, and Jorge Gonzalez, “Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance,” Journal of Endocrinology, vol. 223, no. 1, pp. M17–M29, 2014. View at Publisher · View at Google Scholar
  • Laura Torres-Rovira, Susana Astiz, Pedro Gonzalez-Anover, Pilar Pallares, Sonia Perez-Garnelo, Mariluz Perez-Solana, Raul Sanchez-Sanchez, and Antonio Gonzalez-Bulnes, “Intake of high saturated-fat diets disturbs steroidogenesis, lipid metabolism and development of obese-swine conceptuses from early-pregnancy stages,” Journal of Steroid Biochemistry and Molecular Biology, vol. 139, pp. 130–137, 2014. View at Publisher · View at Google Scholar
  • Cristina Ovilo, Antonio Gonzalez-Bulnes, and Susana Astiz, “Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome,” Current Pharmaceutical Biotechnology, vol. 15, no. 1, pp. 13–23, 2014. View at Publisher · View at Google Scholar
  • Dan Li, Qiang Wang, Yan Zhang, De Li, Dachun Yang, Shujie Wei, Linan Su, Tingqiao Ye, Xi Zheng, Ke Peng, Liping Zhang, Yunrong Zhang, Yongjian Yang, and Shuangtao Ma, “A Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity Responds Well to Renal Denervation,” American Journal of Hypertension, vol. 29, no. 1, pp. 63–72, 2015. View at Publisher · View at Google Scholar
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  • Miriam Ayuso, Almudena Fernandez, Yolanda Nunez, Rita Benitez, Beatriz Isabel, Carmen Barragan, Ana Isabel Fernandez, Ana Isabel Rey, Juan F. Medrano, Angela Canovas, Antonio Gonzalez-Bulnes, Clemente Lopez-Bote, and Cristina Ovilo, “Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabo,” Plos One, vol. 10, no. 12, 2015. View at Publisher · View at Google Scholar
  • Antonio Gonzalez-Bulnes, Laura Torres-Rovira, Susana Astiz, Cristina Ovilo, Raul Sanchez-Sanchez, Ernesto Gomez-Fidalgo, Mariluz Perez-Solana, Mercedes Martin-Lluch, Consuelo Garcia-Contreras, and Marta Vazquez-Gomez, “Fetal Sex Modulates Developmental Response to Maternal Malnutrition,” Plos One, vol. 10, no. 11, 2015. View at Publisher · View at Google Scholar
  • Antonio Gonzalez-Bulnes, and Susana Astiz, “Effects of Lifestyle on Female Reproductive Features and Success: Lessons from Animal Models,” Handbook of Fertility, pp. 191–202, 2015. View at Publisher · View at Google Scholar
  • A. M. Martínez-Montes, A. Fernández, D. Pérez-Montarelo, E. Alves, R. M. Benítez, Y. Nuñez, C. Óvilo, N. Ibañez-Escriche, J. M. Folch, and A. I. Fernández, “Using RNA-Seq SNP data to reveal potential causal mutations related to pig production traits and RNA editing,” Animal Genetics, 2016. View at Publisher · View at Google Scholar
  • Consolación Garcia-Contreras, Marta Vazquez-Gomez, Antonio Gonzalez-Bulnes, Susana Astiz, and Victor H. Parraguez, “Empowering translational research in fetal growth restriction: Sheep and swine animal models,” Current Pharmaceutical Biotechnology, vol. 17, no. 10, pp. 848–855, 2016. View at Publisher · View at Google Scholar
  • Dominic T. Schomberg, Armando Tellez, Jennifer J. Meudt, Dane A. Brady, Krista N. Dillon, Folagbayi K. Arowolo, Joan Wicks, Serge D. Rousselle, and Dhanansayan Shanmuganayagam, “Miniature Swine for Preclinical Modeling of Complexities of Human Disease for Translational Scientific Discovery and Accelerated Development of Therap,” Toxicologic Pathology, vol. 44, no. 3, pp. 299–314, 2016. View at Publisher · View at Google Scholar
  • Simone Renner, Britta Dobenecker, Andreas Blutke, Susanne Zöls, Rüdiger Wanke, Mathias Ritzmann, and Eckhard Wolf, “Comparative aspects of rodent and non-rodent animal models for mechanistic and translational diabetes research,” Theriogenology, 2016. View at Publisher · View at Google Scholar
  • A. Gonzalez-Bulnes, S. Astiz, C. Ovilo, C. Lopez-Bote, L. Torres-Rovira, A. Barbero, M. Ayuso, C. Garcia-Contreras, and M. Vazquez-Gomez, “Developmental Origins of Health and Disease in swine: implications for animal production and biomedical research,” Theriogenology, 2016. View at Publisher · View at Google Scholar
  • Semone B. Myrie, Leslie L. McKnight, J. Christopher King, John J. McGuire, Bruce N. Van Vliet, Sukhinder K. Cheema, and Robert F. Bertolo, “Intrauterine growth-restricted Yucatan miniature pigs experience early catch-up growth, leading to greater adiposity and impaired lipid metabolism as young adults,” Applied Physiology, Nutrition, and Metabolism, pp. 1–8, 2017. View at Publisher · View at Google Scholar
  • Rita Benítez, Almudena Fernández, Beatriz Isabel, Yolanda Núñez, Eduardo De Mercado, Emilio Gómez-Izquierdo, Juan García-Casco, Clemente López-Bote, and Cristina Óvilo, “Modulatory Effects of Breed, Feeding Status, and Diet on Adipogenic, Lipogenic, and Lipolytic Gene Expression in Growing Iberian and Duroc Pigs,” International Journal of Molecular Sciences, vol. 19, no. 1, pp. 22, 2017. View at Publisher · View at Google Scholar
  • Laura Cogollos, Consolacion Garcia-Contreras, Marta Vazquez-Gomez, Susana Astiz, Raul Sanchez-Sanchez, Ernesto Gomez-Fidalgo, Cristina Ovilo, Beatriz Isabel, and Antonio Gonzalez-Bulnes, “Effects of fetal genotype and sex on developmental response to maternal malnutrition,” Reproduction, Fertility and Development, vol. 29, no. 6, pp. 1155, 2017. View at Publisher · View at Google Scholar
  • Alexandra Calle, Clara Barrajón-Masa, Ernesto Gómez-Fidalgo, Mercedes Martín-Lluch, Paloma Cruz-Vigo, Raúl Sánchez-Sánchez, and Miguel Ángel Ramírez, “Iberian pig mesenchymal stem/stromal cells from dermal skin, abdominal and subcutaneous adipose tissues, and peripheral blood: in vitro characterization and migratory properties in inflammation,” Stem Cell Research & Therapy, vol. 9, no. 1, 2018. View at Publisher · View at Google Scholar
  • Yu-Sheng Shi, Chun-Bin Li, Xiao-Ying Li, Jiao Wu, Yang Li, Xin Fu, Yan Zhang, and Wen-Zhong Hu, “Fisetin Attenuates Metabolic Dysfunction in Mice Challenged with a High-Fructose Diet,” Journal of Agricultural and Food Chemistry, 2018. View at Publisher · View at Google Scholar
  • M. Vázquez-Gómez, C. García-Contreras, L. Torres-Rovira, S. Astiz, C. Óvilo, A. González-Bulnes, and B. Isabel, “Maternal undernutrition and offspring sex determine birth-weight, postnatal development and meat characteristics in traditional swine breeds,” Journal of Animal Science and Biotechnology, vol. 9, no. 1, 2018. View at Publisher · View at Google Scholar
  • Consolacion Garcia-Contreras, Marta Vazquez-Gomez, Laura Torres-Rovira, Jorge Gonzalez, Esteban Porrini, Magali Gonzalez-Colaço, Beatriz Isabel, Susana Astiz, and Antonio Gonzalez-Bulnes, “Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity,” International Journal of Molecular Sciences, vol. 19, no. 3, pp. 823, 2018. View at Publisher · View at Google Scholar
  • Laura Torres-Rovira, Maria Victoria Sanz-Fernandez, Susana Astiz, Pedro Gonzalez-Añover, Consolacion García-Contreras, Marta Vazquez-Gomez, Jose Luis Pesantez, and Antonio Gonzalez-Bulnes, “Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study,” International Journal of Reproductive BioMedicine, vol. 16, no. 8, pp. 497–500, 2018. View at Publisher · View at Google Scholar
  • Ahmed Ludvigsen Al-Mashhadi, Christian Bo Poulsen, Karin von Wachenfeldt, Anna-Karin Robertson, Jacob Fog Bentzon, Lars Bo Nielsen, Jesper Thygesen, Lars Poulsen Tolbod, Jens Rolighed Larsen, Søren Kragh Moestrup, Björn Frendéus, Brynjulf Mortensen, Ludovic Drouet, Rozh H. Al-Mashhadi, and Erling Falk, “Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs,” Journal of Diabetes Research, vol. 2018, pp. 1–12, 2018. View at Publisher · View at Google Scholar
  • Rita Benítez, Nares Trakooljul, Yolanda Núñez, Beatriz Isabel, Eduard Murani, Eduardo De Mercado, Emilio Gómez-Izquierdo, Juan García-Casco, Clemente López-Bote, Klaus Wimmers, and Cristina Óvilo, “Breed, Diet, and Interaction Effects on Adipose Tissue Transcriptome in Iberian and Duroc Pigs Fed Different Energy Sources,” Genes, vol. 10, no. 8, pp. 589, 2019. View at Publisher · View at Google Scholar
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