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The Scientific World Journal
Volume 2012, Article ID 524169, 7 pages
http://dx.doi.org/10.1100/2012/524169
Research Article

Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products

1Department of Molecular Pharmacology and Pharmacognosy, Drug Discovery Center, Institute for Scientific Research and High Technology Services, P.O. Box 0843-01103, Panama, Panama
2Smithsonian Tropical Research Institute, P.O. Box 0843-03092, Panama, Panama
3Institute of Biochemistry and Molecular Biology, Rheinische Friedrich-Wilhelms-University, Nussallee 11, 53115 Bonn, Germany
4Department of Plant Biology, University of Illinois at Urbana-Champaign, Room 265, Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL 61801, USA

Received 19 October 2011; Accepted 12 December 2011

Academic Editor: Soichi Miwa

Copyright © 2012 Catherina Caballero-George et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Jakobs, Sorkalla, and Häberlein, “Ligands for fluorescence correlation spectroscopy on G protein-coupled receptors,” Current Medicinal Chemistry, vol. 19, no. 28, pp. 4722–4730, 2012. View at Publisher · View at Google Scholar
  • Rajashri Sridharan, Jeffrey Zuber, Sara M. Connelly, Elizabeth Mathew, and Mark E. Dumont, “Fluorescent Approaches for Understanding Interactions of Ligands with G Protein Coupled Receptors,” Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013. View at Publisher · View at Google Scholar
  • Radek Macháň, and Thorsten Wohland, “Recent applications of fluorescence correlation spectroscopy in live systems,” FEBS Letters, 2014. View at Publisher · View at Google Scholar
  • Rajashri Sridharan, Jeffrey Zuber, Sara M. Connelly, Elizabeth Mathew, and Mark E. Dumont, “Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors,” Biochimica et Biophysica Acta-Biomembranes, vol. 1838, no. 1, pp. 15–33, 2014. View at Publisher · View at Google Scholar
  • Nadir Planes, and Catherina Caballero-George, “Marine and Soil Derived Natural Products: A New Source of Novel Cardiovascular Protective Agents Targeting the Endothelin System,” Planta Medica, vol. 81, no. 8, pp. 630–636, 2015. View at Publisher · View at Google Scholar
  • Thomas Antoine, David Ott, Katharina Ebell, Kerrin Hansen, Luc Henry, Frank Becker, and Stefan Hannus, “Homogeneous time-resolved GPCR-ligand binding assay based on fluorescence cross-correlation spectroscopy,” Analytical Biochemistry, 2016. View at Publisher · View at Google Scholar