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The Scientific World Journal
Volume 2012 (2012), Article ID 560142, 9 pages
Research Article

Effect of a Novel Nonviral Gene Delivery of BMP-2 on Bone Healing

1Center for Musculoskeletal Surgery and Julius Wolff Institute, Charité-University Medicine Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
2Institute for Experimental Oncology and Therapy, Technical University Munich, 81675 Munich, Germany
3Department for Trauma and Reconstructive Surgery, University of Heidelberg, 69118 Heidelberg, Germany
4Berlin-Brandenburg Center for Regenerative Therapies, Charité-University Medicine Berlin, 13353 Berlin, Germany

Received 2 August 2012; Accepted 30 September 2012

Academic Editors: A. Bandyopadhyay and M. Deng

Copyright © 2012 P. Schwabe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

The following is the list of published articles that have cited the current article.

  • Laura Kyllönen, Matteo D’Este, Mauro Alini, and David Eglin, “Local drug delivery for enhancing fracture healing in osteoporotic bone,” Acta Biomaterialia, 2014. View at Publisher · View at Google Scholar
  • Ahmad Oryan, Soodeh Alidadi, Ali Moshiri, and Nicola Maffulli, “Bone regenerative medicine: classic options, novel strategies, and future directions,” Journal of Orthopaedic Surgery and Research, vol. 9, 2014. View at Publisher · View at Google Scholar
  • Georg A. Feichtinger, Anna T. Hofmann, Paul Slezak, Sebastian Schuetzenberger, Martin Kaipel, Ernst Schwartz, Anne Neef, Nikolitsa Nomikou, Thomas Nau, Martijn van Griensven, Anthony P. McHale, and Heinz Redl, “ Sonoporation Increases Therapeutic Efficacy of Inducible and Constitutive BMP2/7 In Vivo Gene Delivery ,” Human Gene Therapy Methods, vol. 25, no. 1, pp. 57–71, 2014. View at Publisher · View at Google Scholar
  • Ahmad Oryan, Soodeh Alidadi, Ali Moshiri, and Amin Bigham-Sadegh, “Bone morphogenetic proteins: A powerful osteoinductive compound with non-negligible side effects and limitations,” BioFactors, 2014. View at Publisher · View at Google Scholar
  • Gonzalo Sánchez-Duffhues, Christian Hiepen, Petra Knaus, and Peter ten Dijke, “Bone morphogenetic protein signaling in bone homeostasis,” Bone, 2015. View at Publisher · View at Google Scholar
  • Kezheng Mao, Jianheng Liu, Xiaojie Lian, Qingde Wang, Xiumei Wang, Wei Mei, and Keya Mao, “Controlled Release of rhBMP-2 and Vancomycin from nHAC/alpha-CSH Scaffold for Treatment of Chronic Osteomyelitis,” Journal Of Biomaterials And Tissue Engineering, vol. 5, no. 4, pp. 294–300, 2015. View at Publisher · View at Google Scholar
  • Katharina Schmidt-Bleek, Bettina M. Willie, Philipp Schwabe, Petra Seemann, and Georg N. Duda, “BMPs in Bone Regeneration: Less is more effective, a paradigm-shift,” Cytokine & Growth Factor Reviews, 2015. View at Publisher · View at Google Scholar
  • Andreas Kolk, Thomas Tischer, Christian Koch, Stephan Vogt, Bernhard Haller, Ralf Smeets, Kilian Kreutzer, Christian Plank, and Oliver Bissinger, “A novel nonviral gene delivery tool of BMP-2 for the reconstitution of critical-size bone defects in rats,” Journal of Biomedical Materials Research Part A, vol. 104, no. 10, pp. 2441–2455, 2016. View at Publisher · View at Google Scholar
  • Saeid Kargozar, Seyed Jafar Hashemian, Mansooreh Soleimani, Peiman Brouki Millan, Mohammad Askari, Vahid Khalaj, Ali Samadikuchaksaraie, Sepideh Hamzehlou, Amir Reza Katebi, Noorahmad Latifi, Masoud Mozafari, and Francesco Baino, “Acceleration of bone regeneration in bioactive glass/gelatin composite scaffolds seeded with bone marrow-derived mesenchymal stem cells over-expressing bone morphogenetic protein-7,” Materials Science and Engineering: C, 2017. View at Publisher · View at Google Scholar